A genome-wide SNP scan reveals two loci associated with the chicken resistance to Marek's disease

被引:29
|
作者
Li, D. F.
Lian, L.
Qu, L. J.
Chen, Y. M.
Liu, W. B.
Chen, S. R.
Zheng, J. X.
Xu, G. Y.
Yang, N.
机构
[1] China Agr Univ, Natl Engn Lab Anim Breeding, Coll Anim Sci & Technol, Beijing 100193, Peoples R China
[2] China Agr Univ, MOA Key Lab Anim Genet & Breeding, Coll Anim Sci & Technol, Beijing 100193, Peoples R China
关键词
genome-wide association study; host resistance; Marek's disease; TYROSINE-PHOSPHATASE PTPN3; AFFECTING SUSCEPTIBILITY; VIRUS-INFECTION; LAYER CHICKENS; PROTEIN; IDENTIFICATION; POPULATION; COMPLEX; GENE; HISTOCOMPATIBILITY;
D O I
10.1111/j.1365-2052.2012.02395.x
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Marek's disease (MD) is a neoplastic disease in chickens, caused by the Marek's disease virus (MDV). To investigate host genetic resistance to MD, we conducted a genome-wide association study (GWAS) on 67 MDV-infected chickens based on a case and control design, including 57 susceptible chickens in the case group and 10 resistant chickens as controls. After searching 38655 valid genomic markers, two SNPs were found to be associated with host resistance to MD. One SNP, rs14527240, reaching chromosome-wide significance level (P<0.01) was located in the SPARC-related modular calcium-binding 1 (SMOC1) gene on GGA5. The other one, GGaluGA156129, reaching genome-wide significance (P<0.05), was located in the protein tyrosine phosphatase, non-receptor type 3 (PTPN3) gene on GGA2. In addition, expression patterns of these two genes in spleens were detected by qPCR. The expression of SMOC1 was significantly up-regulated (P<0.05), whereas the expression of PTNP3 did not show significance when the case group was compared with the control group. Up-regulation of SMOC1 in susceptible spleens suggests its important roles in MD tumorigenesis. This is the first study to investigate MD-resistant loci, and it demonstrates the power of GWASs for mapping genes associated with MD resistance.
引用
收藏
页码:217 / 222
页数:6
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