Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering

被引：334
作者：
Narayanan, Ganesh [1 ,2 ,3 ]
Vernekar, Varadraj N. [1 ,2 ,3 ]
Kuyinu, Eminanuel L. [1 ,2 ,3 ]
Laurencin, Cato T. [1 ,2 ,3 ,4 ,5 ,6 ,7 ,8 ]
机构：
[1] Univ Connecticut, Ctr Hlth, Inst Regenerat Engn, Farmington, CT 06030 USA
[2] Univ Connecticut, Ctr Hlth, Raymond & Beverly Sackler Ctr Biomed Biol Phys &, Farmington, CT 06030 USA
[3] Univ Connecticut, Ctr Hlth, Dept Orthopaed Surg, Farmington, CT 06030 USA
[4] Univ Connecticut, Ctr Hlth, Sch Med, Farmington, CT 06030 USA
[5] Univ Connecticut, Ctr Hlth, Dept Reconstruct Sci, Farmington, CT 06030 USA
[6] Univ Connecticut, Dept Chem & Biomol Engn, Storrs, CT 06269 USA
[7] Univ Connecticut, Dept Biomed Engn, Storrs, CT 06269 USA
[8] Univ Connecticut, Dept Mat Sci & Engn, Storrs, CT 06269 USA
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 107卷
关键词：
Poly (lactic acid); Regenerative Engineering; Growth factors; Small molecules; Bone; Ligament; Cartillage; Meniscus regeneration; ANTERIOR CRUCIATE LIGAMENT; MESENCHYMAL STEM-CELLS; IN-VITRO EVALUATION; 3-DIMENSIONAL ELECTROSPUN SCAFFOLDS; SINTERED MICROSPHERE SCAFFOLDS; GROWTH-FACTOR DELIVERY; LACTIDE-CO-GLYCOLIDE; POLY(LACTIC ACID); MECHANICAL-PROPERTIES; DRUG-DELIVERY;
D O I：
10.1016/j.addr.2016.04.015
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Regenerative engineering converges tissue engineering, advanced materials science, stem cell science, and developmental biology to regenerate complex tissues such as whole limbs. Regenerative engineering scaffolds provide mechanical support and nanoscale control over architecture, topography, and biochemical cues to influence cellular outcome. In this regard, poly (lactic acid) (PIA)-based biomaterials may be considered as a gold standard for many orthopaedic regenerative engineering applications because of their versatility in fabrication, biodegradability, and compatibility with biomolecules and cells. Here we discuss recent developments in PLA-based biomaterials with respect to processability and current applications in the clinical and research settings for bone, ligament, meniscus, and cartilage regeneration. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：247 / 276
页数：30
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