Pursuing the curative blueprint for early myeloma

被引：17

作者：

Roschewski, Mark ^{[1
]}

Korde, Neha ^{[1
]}

Wu, S. Peter ^{[1
]}

Landgren, Ola ^{[1
]}

机构：

[1] NCI, Multiple Myeloma Sect, Ctr Canc Res, Metab Branch,NIH, Bethesda, MD 20892 USA

来源：

BLOOD | 2013年 / 122卷 / 04期

基金：

美国国家卫生研究院;

关键词：

UNDETERMINED SIGNIFICANCE MGUS; PRECEDES MULTIPLE-MYELOMA; FREE LIGHT-CHAIN; MONOCLONAL GAMMOPATHY; RISK-FACTORS; PROGRESSION; SURVIVAL; COMBINATION; EVOLUTION;

D O I：

10.1182/blood-2013-01-481291

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treatment philosophies in multiple myeloma (MM) debate the relative merits of achieving the deepest possible remissions ("curative" doctrine) vs sequential delivery of antimyeloma agents ("control" doctrine). In this paper, we highlight the relevant strengths of each doctrine in the context of modern patient selection strategies, fresh biological insights on MM pathogenesis, agents with improved safety profiles, and emerging molecular and imaging tools. Paramount fundamental questions remain unanswered that require an intense research focus as we pursue a cure for this devastating disease.

引用

页码：486 / 490

页数：5

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