Excretion of Compound M-11 and Its Metabolites with Urine and Feces in Rats

被引：0

作者：

Bastrygin, D. V. ^{[1
]}

Viglinskaya, A. O. ^{[1
]}

Kolyvanov, G. B. ^{[1
]}

Litvin, A. A. ^{[1
]}

Bochkov, P. O. ^{[1
]}

Mozhaeva, T. Ya. ^{[1
]}

Zherdev, V. P. ^{[1
]}

机构：

[1] Russian Acad Med Sci, VV Zakusov Inst Pharmacol, Pharmacokinet Lab, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 05期

关键词：

excretion; compound M-11; metabolites;

D O I：

10.1007/s10517-012-1805-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The excretion of compound M-11 and its metabolites with the urine and feces was studied in rats after intraperitoneal and oral administration in a dose of 25 mg/kg. Experiments showed that 1% metabolites were detected in excretions over 24 h irrespective of the route of administration, while the initial compound was not found even in trace amounts.

引用

页码：707 / 709

页数：3

共 6 条

[1] IDENTIFICATION OF HUMAN LIVER CYTOCHROME-P450 ISOFORMS MEDIATING SECONDARY OMEPRAZOLE METABOLISM [J].

ANDERSSON, T ;

MINERS, JO ;

VERONESE, ME ;

BIRKETT, DJ .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1994, 37 (06) :597-604

[2] EFFECT OF LANSOPRAZOLE ON INTRAGASTRIC PH - COMPARISON BETWEEN MORNING AND EVENING DOSING [J].

HONGO, M ;

OHARA, S ;

HIRASAWA, Y ;

ABE, S ;

ASAKI, S ;

TOYOTA, T .

DIGESTIVE DISEASES AND SCIENCES, 1992, 37 (06) :882-890

[3]

Levy R., 2000, METABOLIC DRUG INTER

[4]

Seredenin S. B., 2007, Eksperimental'naya i Klinicheskaya Farmakologiya, V70, P59

[5]

STEINIJANS VW, 1994, INT J CLIN PHARM TH, V32, P385

[6] Excretion of Afobazole and Its Metabolites with Urine and Feces in Rats [J].

Viglinskaya, A. O. ;

Kolyvanov, G. B. ;

Litvin, A. A. ;

Zherdev, V. P. ;

Seredenin, S. B. .

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 145 (04) :440-442

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