Propofol and sevoflurane combined with remifentanil on the pain index, inflammatory factors and postoperative cognitive function of spine fracture patients

被引：10
作者：
Zhao, Yu [1 ]
Zhang, Hongqi [1 ]
机构：
[1] Jining First Peoples Hosp, Dept Anesthesiol, 6 Jiankang Rd, Jining 272011, Shandong, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2018年 / 15卷 / 04期
关键词：
propofol; sevoflurane; spine fracture patients; VERTEBRAL FRACTURES; VENTILATION; EXPOSURE; ADHESION;
D O I：
10.3892/etm.2018.5898
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of propofol vs. sevoflurane combined with remifentanil on the pain index, inflammatory factors and postoperative cognitive function in spine fracture patients were studied and analyzed. A total of 62 patients with vertebral fracture were randomly divided into the propofol group (P group, n=41) and the sevoflurane group (S group, n=41). P group used induction anesthesia with propofol, and maintained anesthesia via intravenous injection of remifentanil. While patients in S group received induction anesthesia with sevoflurane, and also remifentanil as the maintained anesthesia. Results showed that extubation time, eye-opening time and response time of P group were lower than S group (p<0.05). The VAS score 48 h after surgery in P group was significantly lower than the S group (p<0.05). Levels of IL-6, IL-1, ICAM-1 and MMP-9 in serum in P group were lower than those in S group (p<0.05). Mini-mental state examination (MMSE) score 24 h after surgery in P group was higher than that in S group (p<0.01). Compared with sevoflurane anesthesia, propofol combined with remifentanil anesthesia on spine fracture patients can significantly decrease the pain index and inflammatory reaction, shorten the postoperative recovery time.
引用
收藏
页码：3775 / 3780
页数：6
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