Low-frequency stimulation of the tuberomammillary nucleus facilitates electrical amygdaloid-kindling acquisition in Sprague-Dawley rats

被引：30

作者：

Wu, Deng-Chang ^{[1
]}

Zhu-Ge, Zheng-Bing ^{[1
,2
]}

Yu, Chao-Yang ^{[1
,2
]}

Fang, Qi ^{[1
]}

Wang, Shuang ^{[1
,3
]}

Jin, Chun-Lei ^{[1
]}

Zhang, Shi-Hong ^{[1
]}

Chen, Zhong ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Inst Neurosci, Dept Pharmacol, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Pharm, Hangzhou 310016, Zhejiang, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurol, Hangzhou 310009, Zhejiang, Peoples R China

来源：

NEUROBIOLOGY OF DISEASE | 2008年 / 32卷 / 01期

基金：

中国国家自然科学基金;

关键词：

tuberomammillary nucleus; epilepsy; deep brain stimulation; low-frequency stimulation; kindling; pentylenetetrazol; maximal electroshock;

D O I：

10.1016/j.nbd.2008.07.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Histamine plays a suppressive role in seizure. The tuberomammillary nucleus (TM) is the only locus of histaminergic neurons in the brain. To determine whether deep brain stimulation (DBS) of the TM provides protection against seizures, we tested the effects of low-frequency stimulation (LFS, 1 Hz), high frequency stimulation (HFS, 100 Hz), and electrolytic lesions of the TM on seizures generated by amygdaloid kindling, pentylenetetrazol (PTZ) and maximal electroshock (MES) in rats. LFS of TM accelerated the progression of behavioral seizure stage and increased the mean after discharge duration (ADD) during acquisition Of amygdaloid-kindling seizures, but had no considerable anticonvulsive effect in fully kindled animals. It augmented the MES-induced seizures as well, but had no appreciable effects on PTZ-kindled seizures. In addition, both HFS and bilateral lesions of the TM exacerbated the progression of amygdaloid-kindling seizures. These results Suggest that specific negative sites for DBS exist in the brain, such as the TM. TNs study indicates that it is Crucial to choose a suitable target for DBS in the clinical treatment of epilepsy. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：151 / 156

页数：6

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