Quinolone hybrids and their anti-cancer activities: An overview

被引：177
作者：
Gao, Feng [1 ,2 ,3 ]
Zhang, Xia [1 ]
Wang, Tengfei [4 ]
Xiao, Jiaqi [1 ,2 ]
机构：
[1] Qilu Univ Technol, Acad Adv Interdisciplinary Studies, Shandong Acad Sci, Jinan, Shandong, Peoples R China
[2] Qilu Univ Technol, Sch Chem & Pharmaceut Engn, Shandong Acad Sci, Jinan, Shandong, Peoples R China
[3] Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Imaging, Nanjing, Jiangsu, Peoples R China
[4] Qilu Univ Technol, Shandong Acad Sci, State Key Lab Biobased Mat & Green Papermaking LB, Jinan, Shandong, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 165卷
关键词：
Quinolone; Hybrid compounds; Anti-Cancer; Structure-activity relationship; ANTITUMOR-ACTIVITY; BIOLOGICAL EVALUATION; IN-VITRO; POTENTIAL ANTITUMOR; PHOTOCHEMICAL-SYNTHESIS; DNA-BINDING; ACID-DERIVATIVES; CANCER-CELL; FLUOROQUINOLONE DERIVATIVES; ANTIPROLIFERATIVE ACTIVITY;
D O I：
10.1016/j.ejmech.2019.01.017
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The global pandemic of drug-sensitive cancers and the increasing threat from drug-resistant cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone derivatives possess promising anti-cancer activity, and some of them have already been approved to treat cancers or under clinical trials. Hybridization of quinolone with other anti-cancer pharmacophores may provide more efficient anti-cancer candidates, so quinolone hybrids worth to be investigated. In this review, the recent advances in the development of novel quinolone hybrids as potential anti-cancer agents are highlighted, and the structure-activity relationship is also discussed to provide an insight for further development of more active quinolone hybrids. (C) 2019 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：59 / 79
页数：21
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