Quinolone hybrids and their anti-cancer activities: An overview

被引：176

作者：

Gao, Feng ^{[1
,2
,3
]}

Zhang, Xia ^{[1
]}

Wang, Tengfei ^{[4
]}

Xiao, Jiaqi ^{[1
,2
]}

机构：

[1] Qilu Univ Technol, Acad Adv Interdisciplinary Studies, Shandong Acad Sci, Jinan, Shandong, Peoples R China

[2] Qilu Univ Technol, Sch Chem & Pharmaceut Engn, Shandong Acad Sci, Jinan, Shandong, Peoples R China

[3] Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Imaging, Nanjing, Jiangsu, Peoples R China

[4] Qilu Univ Technol, Shandong Acad Sci, State Key Lab Biobased Mat & Green Papermaking LB, Jinan, Shandong, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 165卷

关键词：

Quinolone; Hybrid compounds; Anti-Cancer; Structure-activity relationship; ANTITUMOR-ACTIVITY; BIOLOGICAL EVALUATION; IN-VITRO; POTENTIAL ANTITUMOR; PHOTOCHEMICAL-SYNTHESIS; DNA-BINDING; ACID-DERIVATIVES; CANCER-CELL; FLUOROQUINOLONE DERIVATIVES; ANTIPROLIFERATIVE ACTIVITY;

D O I：

10.1016/j.ejmech.2019.01.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The global pandemic of drug-sensitive cancers and the increasing threat from drug-resistant cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone derivatives possess promising anti-cancer activity, and some of them have already been approved to treat cancers or under clinical trials. Hybridization of quinolone with other anti-cancer pharmacophores may provide more efficient anti-cancer candidates, so quinolone hybrids worth to be investigated. In this review, the recent advances in the development of novel quinolone hybrids as potential anti-cancer agents are highlighted, and the structure-activity relationship is also discussed to provide an insight for further development of more active quinolone hybrids. (C) 2019 Elsevier Masson SAS. All rights reserved.

引用

页码：59 / 79

页数：21

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