A modular synthesis of dithiocarbamate pendant unnatural α-amino acids

被引：34

作者：

Saha, Amit ^{[1
]}

Baig, R. B. Nasir ^{[1
]}

Leazer, John ^{[1
]}

Varma, Rajender S. ^{[1
]}

机构：

[1] US EPA, Sustainable Technol Div, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 71期

关键词：

ONE-POT SYNTHESIS; PYRROLIDINE DITHIOCARBAMATE; EFFICIENT SYNTHESIS; FACILE ENTRY; S-ARYL; DERIVATIVES; CHEMISTRY; BETA; ISOTHIOCYANATE; HETEROCYCLES;

D O I：

10.1039/c2cc32894a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Unnatural alpha-amino acids containing dithiocarbamate side chains were synthesized by a one-pot reaction of in situ generated dithiocarbamate anions with sulfamidates. A wide range of these anions participated in the highly regio- and stereo-selective ring opening of sulfamidates to produce the corresponding dithiocarbamate pendant alpha-amino acids in high yields.

引用

页码：8889 / 8891

页数：3

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