Spectrophotometric studies of Diazepam β-cyclodextrin complex formation

被引：0

作者：

Kacso, Irina ^{[1
]}

Bratu, Ioan ^{[1
]}

Farcas, Andreea ^{[2
]}

Bojita, Marius ^{[2
]}

机构：

[1] Natl Inst R&D Isotop & Mol Technol, RO-400293 Cluj Napoca, Romania

[2] Univ Med & Pharm Iuliu Hatieganu, Cluj Napoca, Romania

来源：

STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA | 2007年 / 52卷 / 04期

关键词：

FTIR; UV-Vis; stoichiometry; association constant; inclusion compound; beta-cyclodextrin;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Solid state interactions between a bioactive substance-Diazepam and beta-cyclodextrin (beta-CD) - the so called inclusion compounds ( obtained by different preparation methods: kneading, co-precipitation and freeze-drying) were investigated. The obtained compounds were investigated by FTIR spectroscopy to evidence their formation. The results revealed that the solid state inclusion compound, such as Diazepam/beta-cyclodextrin has a good stability. The stoichiometry of the inclusion complexes of diazepam with beta-CD is 1:1 was investigated in solution. The association constant of the complex was determined by UV spectrophotometry. The encapsulation might improve Diazepam stability and bioavailability of the drug.

引用

页码：131 / 136

页数：6

共 50 条

[41] Exploring the Recognition Mechanism of Surfactant-Cyclodextrin Complex Formation: Insights from SPR Studies on Temperature and Ionic Liquid Influence
Marques, Isabela Araujo
de Paula, Hauster Maximiler Campos
Silva, Camilla Fonseca
Nascimento Jr, Clebio Soares
Coelho, Yara Luiza
Pires, Ana Clarissa dos Santos
da Silva, Luis Henrique Mendes
JOURNAL OF PHYSICAL CHEMISTRY B, 2024, 128 (39): : 9604 - 9612
[42] Crystal structure of the inclusion complex of cholesterol in β-cyclodextrin and molecular dynamics studies
Christoforides, Elias
Papaioannou, Andreas
Bethanis, Kostas
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2018, 14 : 838 - 848
[43] Studies on inclusion compound of quercetin with β-cyclodextrin
Shao, W
Wang, JS
Wang, CX
Mi, GT
Wang, DQ
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 1998, 19 (07): : 1101 - 1103
[44] Supramolecular inclusion complex formation and application of β-cyclodextrin with heteroanthracene ring cationic dyes
Yuan, ZB
Zhu, M
Han, SB
ANALYTICA CHIMICA ACTA, 1999, 389 (1-3) : 291 - 298
[45] Thermodynamics of inclusion complex formation of β-cyclodextrin with a variety of surfactants differing in the nature of headgroup
Benko, Maria
Kiraly, Zoltan
JOURNAL OF CHEMICAL THERMODYNAMICS, 2012, 54 : 211 - 216
[46] Quenching of Singlet Oxygen by a Carotenoid-Cyclodextrin Complex: The Importance of Aggregate Formation
Kanofsky, Jeffrey R.
Sima, Paul D.
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2009, 85 (01) : 391 - 399
[47] Enhanced Solubility, Stability, and Herbicidal Activity of the Herbicide Diuron by Complex Formation with β-Cyclodextrin
Gao, Shuang
Jiang, Jing-Yu
Liu, Yan-Yan
Fu, Ying
Zhao, Li-Xia
Li, Chun-Yan
Ye, Fei
POLYMERS, 2019, 11 (09)
[48] Nanoparticle formation of lycopene/β-cyclodextrin inclusion complex using supercritical antisolvent precipitation
Nerome, Hazuki
Machmudah, Siti
Wahyudiono
Fukuzato, Ryuichi
Higashiura, Takuma
Youn, Yong-Suk
Lee, Youn-Woo
Goto, Motonobu
JOURNAL OF SUPERCRITICAL FLUIDS, 2013, 83 : 97 - 103
[49] Structural Evaluation of Crystalline Ternary γ-Cyclodextrin Complex
Higashi, Kenjirou
Ideura, Saori
Waraya, Haruka
Moribe, Kunikazu
Yamamoto, Keiji
JOURNAL OF PHARMACEUTICAL SCIENCES, 2011, 100 (01) : 325 - 333
[50] Encapsulation of nabumetone by means of -drug:: (β-cyclodextrin)2:polyvinylpyrrolidone ternary complex formation
Valero, Margarita
Tejedor, Javier
Rodriguez, Licesio J.
JOURNAL OF LUMINESCENCE, 2007, 126 (02) : 297 - 302

← 1 2 3 4 5 →