Spectrophotometric studies of Diazepam β-cyclodextrin complex formation

被引：0

作者：

Kacso, Irina ^{[1
]}

Bratu, Ioan ^{[1
]}

Farcas, Andreea ^{[2
]}

Bojita, Marius ^{[2
]}

机构：

[1] Natl Inst R&D Isotop & Mol Technol, RO-400293 Cluj Napoca, Romania

[2] Univ Med & Pharm Iuliu Hatieganu, Cluj Napoca, Romania

来源：

STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA | 2007年 / 52卷 / 04期

关键词：

FTIR; UV-Vis; stoichiometry; association constant; inclusion compound; beta-cyclodextrin;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Solid state interactions between a bioactive substance-Diazepam and beta-cyclodextrin (beta-CD) - the so called inclusion compounds ( obtained by different preparation methods: kneading, co-precipitation and freeze-drying) were investigated. The obtained compounds were investigated by FTIR spectroscopy to evidence their formation. The results revealed that the solid state inclusion compound, such as Diazepam/beta-cyclodextrin has a good stability. The stoichiometry of the inclusion complexes of diazepam with beta-CD is 1:1 was investigated in solution. The association constant of the complex was determined by UV spectrophotometry. The encapsulation might improve Diazepam stability and bioavailability of the drug.

引用

页码：131 / 136

页数：6

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