Neolignans and Sesquiterpenes from Cell Cultures of Stellera chamaejasme

被引：30

作者：

Qiao, Li-Rui ^{[1
,2
,3
]}

Yang, Lin ^{[1
,2
,3
]}

Zou, Jian-Hua ^{[1
,2
,3
]}

Li, Li ^{[1
,2
,3
]}

Sun, Hua ^{[1
,2
,3
]}

Si, Yi-Kang ^{[1
,2
,3
]}

Zhang, Dan ^{[1
,2
,3
]}

Chen, Xiaoguang ^{[1
,2
,3
]}

Dai, Jungui ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Minist Hlth, State Key Lab Bioact Subst & Funct Nat Med, 1 Xian Nong Tan St, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, Minist Hlth, Key Lab Biosynth Nat Prod, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

PLANTA MEDICA | 2012年 / 78卷 / 07期

关键词：

Stellera chamaejasme L; Thymelaeaceae; callus cultures; sesquiterpenes; density functional theory; CCl4-induced hepatotoxicity; CALLUS-CULTURE; CONSTITUENTS; LIGNANS; NORSESQUITERPENES; BICYCLOL;

D O I：

10.1055/s-0031-1298380

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new neolignans (1,2) and six sesquiterpenes (3-8) were isolated from the cell cultures of Stellera chamaejasme. Their structures and absolute configurations were elucidated by extensive spectroscopic and computational methods. Compound 4 exhibited significant protective effects against CCl4-induced hepatotoxicity in HepG2 cells, reducing aspartate aminotransferase release by 29.49% at 10 mu M. These compounds have not been isolated from plant material, which implies that in vitro plant cell cultures may offer alternative and effective sources of bioactive natural compounds.

引用

页码：711 / 719

页数：9

共 34 条

[1] Chiroptical properties of 2,3-dihydrobenzo[b]furan and chromane chromophores in naturally occurring O-heterocycles [J].