Synthesis and antiproliferative activity of new chlorin e6 glycoconjugates

被引：15

作者：

Kuzmina, Natalia S. ^{[1
]}

Otvagin, Vasilii F. ^{[1
]}

Krylova, Lubov V. ^{[1
]}

Nyuchev, Alexander V. ^{[1
]}

Romanenko, Yuliya V. ^{[2
]}

Koifman, Oscar I. ^{[2
]}

Balalaeva, Irina V. ^{[1
]}

Fedorov, Alexey Yu. ^{[1
]}

机构：

[1] NI Lobachevsky State Univ Nizhny Novgorod, Nizhnii Novgorod, Russia

[2] Ivanovo State Univ Chem & Technol, Res Inst Macroheterocycles, Ivanovo 153000, Russia

来源：

MENDELEEV COMMUNICATIONS | 2020年 / 30卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

chlorin e(6); glycoconjugate; water soluble; A431; cells; photodynamic therapy; PHOTODYNAMIC THERAPY; CANCER; PHOTOSENSITIZERS; DELIVERY; PORPHYRINS; CONJUGATE;

D O I：

10.1016/j.mencom.2020.03.009

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New water soluble conjugates of chlorin e(6) derivative-zinc complex with beta-d-galactose or beta-d-glucose have been synthesized as potential agents for the photodynamic therapy of cancer. They exhibit photoinduced cytotoxicity at low micromolar concentrations with IC50(dark)/IC50(light) ratio of similar to 50.

引用

页码：159 / 161

页数：3

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