Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

被引：22

作者：

Niu, Weining ^{[1
]}

Wu, Ping ^{[1
]}

Chen, Fei ^{[1
]}

Wang, Jun ^{[1
]}

Shang, Xiaoya ^{[1
]}

Xu, Chunlan ^{[1
]}

机构：

[1] Northwestern Polytech Univ, Sch Life Sci, Key Lab Space Biosci & Space Biotechnol, Xian 710072, Peoples R China

来源：

MEDCHEMCOMM | 2017年 / 8卷 / 01期

基金：

中国国家自然科学基金;

关键词：

HYDROGEN-SULFIDE; COLON-CANCER; HOMOCYSTINURIA; MUTATIONS; THERAPY;

D O I：

10.1039/c6md00493h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A high-throughput assay was developed to identify inhibitors of cystathionine beta-synthase (CBS), which is one of three key enzymes involved in H2S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC50 values of less than 10 mu M.

引用

页码：198 / 201

页数：4

共 50 条

[41] A highly selective and sensitive fluorescent thiol probe through dual-reactive and dual-quenching groups
Zhang, Huatang
Zhang, Changyu
Liu, Ruochuan
Yi, Long
Sun, Hongyan
CHEMICAL COMMUNICATIONS, 2015, 51 (11) : 2029 - U44
[42] A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells
Ricci, F.
Carrassa, L.
Christodoulou, M. S.
Passarella, D.
Michel, B.
Benhida, R.
Martinet, N.
Hunyadi, A.
Ioannou, E.
Roussis, V.
Musso, L.
Dallavalle, S.
Silvestri, R.
Westwood, N.
Mori, M.
Ingallina, C.
Botta, B.
Kavetsou, E.
Detsi, A.
Majer, Z.
Hudecz, F.
Bosze, S.
Kaminska, B.
Hansen, T. V.
Bertrand, P.
Athanassopoulos, C. M.
Damia, G.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2018, 21 (01) : 50 - 56
[43] Identification of the Benzoimidazole Compound as a Selective FLT3 Inhibitor by Cell-Based High-Throughput Screening of a Diversity Library
Tian, Tian
Zhang, Shengyi
Luo, Bingling
Yin, Feng
Lu, Wenhua
Li, Yiqing
Huang, Kezhi
Liu, Qiao
Huang, Peng
Garcia-Manero, G.
Wen, Shijun
Hu, Yumin
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (04) : 3597 - 3605
[44] Identification of genes required for eye development by high-throughput screening of mouse knockouts
Moore, Bret A.
Leonard, Brian C.
Sebbag, Lionel
Edwards, Sydney G.
Cooper, Ann
Imai, Denise M.
Straiton, Ewan
Santos, Luis
Reilly, Christopher
Griffey, Stephen M.
Bower, Lynette
Clary, David
Mason, Jeremy
Roux, Michel J.
Meziane, Hamid
Herault, Yann
McKerlie, Colin
Flenniken, Ann M.
Nutter, Lauryl M. J.
Berberovic, Zorana
Owen, Celeste
Newbigging, Susan
Adissu, Hibret
Eskandarian, Mohammed
Hsu, Chih-Wei
Kalaga, Sowmya
Udensi, Uchechukwu
Asomugha, Chinwe
Bohat, Ritu
Gallegos, Juan J.
Seavitt, John R.
Heaney, Jason D.
Beaudet, Arthur L.
Dickinson, Mary E.
Justice, Monica J.
Philip, Vivek
Kumar, Vivek
Svenson, Karen L.
Braun, Robert E.
Wells, Sara
Cater, Heather
Stewart, Michelle
Clementson-Mobbs, Sharon
Joynson, Russell
Gao, Xiang
Suzuki, Tomohiro
Wakana, Shigeharu
Smedley, Damian
Seong, J. K.
Tocchini-Valentini, Glauco
COMMUNICATIONS BIOLOGY, 2018, 1
[45] High-Throughput Screening for the Identification of New Therapeutic Options for Metastatic Pheochromocytoma and Paraganglioma
Giubellino, Alessio
Shankavaram, Uma
Bullova, Petra
Schovanek, Jan
Zhang, Yaqin
Shen, Min
Patel, Nikita
Elkahloun, Abdel
Lee, Min-Jung
Trepel, Jane
Ferrer, Marc
Pacak, Karel
PLOS ONE, 2014, 9 (04):
[46] In Silico-Based High-Throughput Screen for Discovery of Novel Combinations for Tuberculosis Treatment
Singh, Ragini
Ramachandran, Vasanthi
Shandil, Radha
Sharma, Sreevalli
Khandelwal, Swati
Karmarkar, Malancha
Kumar, Naveen
Solapure, Suresh
Saralaya, Ramanatha
Nanduri, Robert
Panduga, Vijender
Reddy, Jitendar
Prabhakar, K. R.
Rajagopalan, Swaminathan
Rao, Narasimha
Narayanan, Shridhar
Anandkumar, Anand
Balasubramanian, V.
Dattaa, Santanu
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (09) : 5664 - 5674
[47] High-Throughput Biochemical Kinase Selectivity Assays: Panel Development and Screening Applications
Card, Amy
Caldwell, Chris
Min, Hyunsuk
Lokchander, Bina
Xi, Hualin
Sciabola, Simone
Kamath, Ajith V.
Clugston, Susan L.
Tschantz, William R.
Wang, Leyu
Moshinsky, Deborah J.
JOURNAL OF BIOMOLECULAR SCREENING, 2009, 14 (01) : 31 - 42
[48] Conditionally Reprogrammed Cells and Robotic High-Throughput Screening for Precision Cancer Therapy
Alkhilaiwi, Faris
FRONTIERS IN ONCOLOGY, 2021, 11
[49] High-Throughput Screening for Salmonella Avirulent Mutants That Retain Targeting of Solid Tumors
Arrach, Nabil
Cheng, Pui
Zhao, Ming
Santiviago, Carlos A.
Hoffman, Robert M.
McClelland, Michael
CANCER RESEARCH, 2010, 70 (06) : 2165 - 2170
[50] Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening
Han, Jie
Tian, Yucheng
Yu, Liang
Zhang, Qilin
Xu, Xi
Zhang, Yichao
Wang, Jubo
Ma, Zengyi
Bian, Jinlei
Luo, Cheng
Jiang, Hualiang
Chen, Kaixian
Zhao, Yao
Li, Zhiyu
Ding, Hong
BIOORGANIC CHEMISTRY, 2020, 101

← 1 2 3 4 5 →