Safety and Efficacy of Imatinib for Hospitalized Adults with COVID-19: A structured summary of a study protocol for a randomised controlled trial

被引:31
作者
Emadi, Ashkan [1 ,2 ,3 ]
Chua, Joel V. [2 ,4 ]
Talwani, Rohit [2 ,4 ]
Bentzen, Soren M. [1 ,5 ]
Baddley, John [1 ,2 ,4 ]
机构
[1] Univ Maryland, Marlene & Stewart Greenebaum Comprehens Canc Ctr, 22 South Greene St,Room N9E06, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA
[3] Univ Maryland, Sch Med, Dept Pharmacol, Baltimore, MD 21201 USA
[4] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA
[5] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA
关键词
COVID-19; Randomised controlled trial; protocol; SARS-CoV; imatinib; tyrosine kinase inhibitor; TKI; lysosomal sequestration; viral ABL-1 signalling; TKI-induced attenuation of vascular leak; TKI-induced prevention and treatment lung inflammation;
D O I
10.1186/s13063-020-04819-9
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页数:5
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