Safety and Efficacy of Imatinib for Hospitalized Adults with COVID-19: A structured summary of a study protocol for a randomised controlled trial

被引：31
作者：
Emadi, Ashkan [1 ,2 ,3 ]
Chua, Joel V. [2 ,4 ]
Talwani, Rohit [2 ,4 ]
Bentzen, Soren M. [1 ,5 ]
Baddley, John [1 ,2 ,4 ]
机构：
[1] Univ Maryland, Marlene & Stewart Greenebaum Comprehens Canc Ctr, 22 South Greene St,Room N9E06, Baltimore, MD 21201 USA
[2] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA
[3] Univ Maryland, Sch Med, Dept Pharmacol, Baltimore, MD 21201 USA
[4] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA
[5] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA
来源：
TRIALS | 2020年 / 21卷 / 01期
关键词：
COVID-19; Randomised controlled trial; protocol; SARS-CoV; imatinib; tyrosine kinase inhibitor; TKI; lysosomal sequestration; viral ABL-1 signalling; TKI-induced attenuation of vascular leak; TKI-induced prevention and treatment lung inflammation;
D O I：
10.1186/s13063-020-04819-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
引用
收藏
页数：5
相关论文
共 50 条
[11]   Treatment of COVID-19 pneumonia with glucocorticoids (CORTIVID): a structured summary of a study protocol for a randomised controlled trial [J].
Iñigo Les Bujanda ;
Jose Loureiro-Amigo ;
Ferran Capdevila Bastons ;
Iñaki Elejalde Guerra ;
Javier Anniccherico Sánchez ;
Anna Murgadella-Sancho ;
Ruth García Rey ;
Julián Librero López ;
Julio Sánchez Álvarez .
Trials, 22
[12]   Treatment of COVID-19 pneumonia with glucocorticoids (CORTIVID): a structured summary of a study protocol for a randomised controlled trial [J].
Bujanda, Inigo Les ;
Loureiro-Amigo, Jose ;
Capdevila Bastons, Ferran ;
Elejalde Guerra, Inaki ;
Anniccherico Sanchez, Javier ;
Murgadella-Sancho, Anna ;
Garcia Rey, Ruth ;
Librero Lopez, Julian ;
Sanchez Alvarez, Julio .
TRIALS, 2021, 22 (01)
[13]   Efficacy and safety of nitazoxanide plus atazanavir/ritonavir for the treatment of moderate to severe COVID-19 (NACOVID): A structured summary of a study protocol for a randomised controlled trial [J].
Adeniyi Olagunju ;
Adeola Fowotade ;
Ajibola Olagunoye ;
Temitope Olumuyiwa Ojo ;
Bolanle Olufunlola Adefuye ;
Adeniyi Francis Fagbamigbe ;
Akindele Olupelumi Adebiyi ;
Omobolanle Ibitayo Olagunju ;
Olabode Taiwo Ladipo ;
Abdulafeez Akinloye ;
Babatunde Ayodeji Adeagbo ;
Adedeji Onayade ;
Oluseye Oladotun Bolaji ;
Christian Happi ;
Steve Rannard ;
Andrew Owen .
Trials, 22
[14]   Efficacy and safety of nitazoxanide plus atazanavir/ritonavir for the treatment of moderate to severe COVID-19 (NACOVID): A structured summary of a study protocol for a randomised controlled trial [J].
Olagunju, Adeniyi ;
Fowotade, Adeola ;
Olagunoye, Ajibola ;
Ojo, Temitope Olumuyiwa ;
Adefuye, Bolanle Olufunlola ;
Fagbamigbe, Adeniyi Francis ;
Adebiyi, Akindele Olupelumi ;
Olagunju, Omobolanle Ibitayo ;
Ladipo, Olabode Taiwo ;
Akinloye, Abdulafeez ;
Adeagbo, Babatunde Ayodeji ;
Onayade, Adedeji ;
Bolaji, Oluseye Oladotun ;
Happi, Christian ;
Rannard, Steve ;
Owen, Andrew .
TRIALS, 2021, 22 (01)
[15]   Safety and efficacy of antiviral combination therapy in symptomatic patients of Covid-19 infection-a randomised controlled trial (SEV-COVID Trial): A structured summary of a study protocol for a randomized controlled trial [J].
Panda, Prasan Kumar ;
Bandyopadhyay, Arkapal ;
Singh, Budha Charan ;
Moirangthem, Bikram ;
Chikara, Gaurav ;
Saha, Sarama ;
Bahurupi, Yogesh Arvind .
TRIALS, 2020, 21 (01)
[16]   Evaluation of the efficacy and safety of Melatonin in moderately ill patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial [J].
Ziaei, Ava ;
Davoodian, Parivash ;
Dadvand, Habib ;
Safa, Omid ;
Hassanipour, Soheil ;
Omidi, Mahmoud ;
Masjedi, Moein ;
Mahmoudikia, Fahime ;
Rafiee, Bahareh ;
Fathalipour, Mohammad .
TRIALS, 2020, 21 (01)
[17]   Evaluation of the efficacy and safety of Melatonin in moderately ill patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial [J].
Ava Ziaei ;
Parivash Davoodian ;
Habib Dadvand ;
Omid Safa ;
Soheil Hassanipour ;
Mahmoud Omidi ;
Moein Masjedi ;
Fahime Mahmoudikia ;
Bahareh Rafiee ;
Mohammad Fathalipour .
Trials, 21
[18]   Early antiviral treatment in outpatients with COVID-19 (FLARE): a structured summary of a study protocol for a randomised controlled trial [J].
Li-An K. Brown ;
Nick Freemantle ;
Judy Breuer ;
Hakim-Moulay Dehbi ;
Kashfia Chowdhury ;
Gemma Jones ;
Felicia Ikeji ;
Amalia Ndoutoumou ;
Krishneya Santhirakumar ;
Nicky Longley ;
Anna M. Checkley ;
Joseph F. Standing ;
David M. Lowe .
Trials, 22
[19]   Early antiviral treatment in outpatients with COVID-19 (FLARE): a structured summary of a study protocol for a randomised controlled trial [J].
Brown, Li-An K. ;
Freemantle, Nick ;
Breuer, Judy ;
Dehbi, Hakim-Moulay ;
Chowdhury, Kashfia ;
Jones, Gemma ;
Ikeji, Felicia ;
Ndoutoumou, Amalia ;
Santhirakumar, Krishneya ;
Longley, Nicky ;
Checkley, Anna M. ;
Standing, Joseph F. ;
Lowe, David M. .
TRIALS, 2021, 22 (01)
[20]   A prospective, randomised, double blind placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia (TOC-COVID): A structured summary of a study protocol for a randomised controlled trial [J].
Jonathan Rilinger ;
Winfried V. Kern ;
Daniel Duerschmied ;
Alexander Supady ;
Christoph Bode ;
Dawid L. Staudacher ;
Tobias Wengenmayer .
Trials, 21
12345