A New Tetrahydrofuran Lignan Diglycoside from Viola tianshanica Maxim

被引：23

作者：

Qin, Yan ^{[1
]}

Yin, Chengle ^{[1
]}

Cheng, Zhihong ^{[1
,2
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China

[2] Jiangxi Univ Tradit Chinese Med, Key Lab Modern Chinese Preparat, Minist Educ China, Nanchang 330004, Peoples R China

来源：

MOLECULES | 2013年 / 18卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Viola tianshanica; lignan; tianshanoside A; cytotoxicity; GLYCOSIDES;

D O I：

10.3390/molecules181113636

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new lignan glycoside, tianshanoside A (1), together with a known phenylpropanoid glycoside, syringin (2) and two known lignan glycosides, picraquassioside C (3), and aketrilignoside B (4), were isolated from the whole plant of Viola tianshanica Maxim. The structure of the new compound was elucidated by extensive NMR (H-1, C-13, COSY, HSQC, HMBC and ROESY) and high resolution mass spectrometry analysis. The three lignans 1, 3, and 4 did not exhibit significant cytotoxicity against human gastric cancer Ags cells or HepG2 liver cancer cells. This is the first report of the isolation of a lignan skeleton from the genus Viola L.

引用

页码：13636 / 13644

页数：9

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