Animal Models for Dysphagia Studies: What Have We Learnt So Far

被引:48
|
作者
German, Rebecca Z. [1 ]
Crompton, A. W. [2 ]
Gould, Francois D. H. [1 ]
Thexton, Allan J. [3 ]
机构
[1] Northeast Ohio Med Univ, Dept Anat & Neurosci, Rootstown, OH 44272 USA
[2] Harvard Univ, Museum Comparat Zool, Cambridge, MA 02138 USA
[3] Kings Coll London, Div Physiol, Guys Campus, London SE1 9RT, England
关键词
Animal models; Performance; Pathophysiology; Deglutition; Deglutition disorders; SUPERIOR LARYNGEAL NERVE; WIRE INTRAMUSCULAR ELECTRODES; RAT MODEL; ELECTRICAL-STIMULATION; SWALLOWING REFLEX; SILENT ASPIRATION; TONGUE FORCE; ELECTROMYOGRAPHY; INFANT; LESION;
D O I
10.1007/s00455-016-9778-7
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Research using animal models has contributed significantly to realizing the goal of understanding dysfunction and improving the care of patients who suffer from dysphagia. But why should other researchers and the clinicians who see patients day in and day out care about this work? Results from studies of animal models have the potential to change and grow how we think about dysphagia research and practice in general, well beyond applying specific results to human studies. Animal research provides two key contributions to our understanding of dysphagia. The first is a more complete characterization of the physiology of both normal and pathological swallow than is possible in human subjects. The second is suggesting of specific, physiological, targets for development and testing of treatment interventions to improve dysphagia outcomes.
引用
收藏
页码:73 / 77
页数:5
相关论文
共 50 条
  • [41] ANCA-small vessel vasculitides: what have we (not yet) learned from animal models?
    Van Der Veen, Betty S.
    Heeringa, Peter
    APMIS, 2009, 117 : 21 - 26
  • [42] Animal models of arrhythmogenic right ventricular cardiomyopathy: what have we learned and where do we go? Insight for therapeutics
    Laura Padrón-Barthe
    Fernando Domínguez
    Pablo Garcia-Pavia
    Enrique Lara-Pezzi
    Basic Research in Cardiology, 2017, 112
  • [43] Animal models of arrhythmogenic right ventricular cardiomyopathy: what have we learned and where do we go? Insight for therapeutics
    Padron-Barthe, Laura
    Dominguez, Fernando
    Garcia-Pavia, Pablo
    Lara-Pezzi, Enrique
    BASIC RESEARCH IN CARDIOLOGY, 2017, 112 (05)
  • [44] Sleep extension in athletes: what we know so far - A systematic review
    Silva, Aldo Coelho
    Silva, Andressa
    Edwards, Ben J.
    Tod, David
    Amaral, Adriana Souza
    Borba, Diego de Alcantara
    Grade, Isadora
    de Mello, Marco Tulio
    SLEEP MEDICINE, 2021, 77 : 128 - 135
  • [45] COX-2 in liver, from regeneration to hepatocarcinogenesis: What we have learned from animal models?
    Martin-Sanz, Paloma
    Mayoral, Rafael
    Casado, Marta
    Bosca, Lisardo
    WORLD JOURNAL OF GASTROENTEROLOGY, 2010, 16 (12) : 1430 - 1435
  • [46] COX-2 in liver,from regeneration to hepatocarcinogenesis:What we have learned from animal models?
    Paloma Martín-Sanz
    Rafael Mayoral
    Marta Casado
    Lisardo Boscá
    World Journal of Gastroenterology, 2010, 16 (12) : 1430 - 1435
  • [47] What We Have Learned from Animal Models to Understand the Etiology and Pathology of Endometrioma-Related Infertility
    Tan, Zhouyurong
    Hung, Sze-Wan
    Zheng, Xu
    Wang, Chi-Chiu
    Chung, Jacqueline Pui-Wah
    Zhang, Tao
    BIOMEDICINES, 2022, 10 (07)
  • [48] Human resource management in times of crisis: what have we learnt from the recent pandemic?
    Newman, Alexander
    Ferrer, Justine
    Andresen, Maike
    Zhang, Yucheng
    INTERNATIONAL JOURNAL OF HUMAN RESOURCE MANAGEMENT, 2023, 34 (15) : 2857 - 2875
  • [49] Investigational cannabinoids in seizure disorders, what have we learned thus far?
    Zecevic, Dejana Ruzic
    Folic, Marko
    Tantoush, Ziyad
    Radovanovic, Milan
    Babic, Goran
    Jankovic, Slobodan M.
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2018, 27 (06) : 535 - 541
  • [50] New knowledge on the pathogenesis of chronic inflammatory bowel disease:: what have we learned from colitis animal models
    Seibold, F
    Egger, B
    Göke, B
    SCHWEIZERISCHE MEDIZINISCHE WOCHENSCHRIFT, 2000, 130 (20) : 749 - 755