Tyrosinase inhibitory components from Aloe vera and their antiviral activity

被引：38

作者：

Kim, Jang Hoon ^{[1
]}

Yoon, Ju-Yeon ^{[1
]}

Yang, Seo Young ^{[2
]}

Choi, Seung-Kook ^{[1
]}

Kwon, Sun Jung ^{[1
]}

Cho, In Sook ^{[1
]}

Jeong, Min Hee ^{[2
]}

Kim, Young Ho ^{[2
]}

Choi, Gug Seoun ^{[1
]}

机构：

[1] Natl Inst Hort & Herbal Sci, Dept Hort & Crop Environm, RDA, Wonju 55365, South Korea

[2] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2017年 / 32卷 / 01期

关键词：

Aloe vera; molecular docking; Pepper mild mottle virus; tyrosinase; Xanthorrhoeaceae; MUSHROOM TYROSINASE; L; GEL; CONSTITUENTS; KINETICS;

D O I：

10.1080/14756366.2016.1235568

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight known compounds (2-9) were isolated from Aloe vera. Their structures were elucidated using 1D/2D nuclear magnetic resonance and mass spectra. Compound 9 exhibited reversible competitive inhibitory activity against the enzyme tyrosinase, with an IC50 value of 9.8 +/- 0.9 mu M. A molecular simulation revealed that compound 9 interacts via hydrogen bonding with residues His244, Thr261, and Val283 of tyrosinase. Additionally, compounds 3 and 7 were shown by half-leaf assays to exhibit inhibitory activity towards Pepper mild mottle virus.

引用

页码：78 / 83

页数：6

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