Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation

被引：23

作者：

Cunningham, Peter S. ^{[1
]}

Maidstone, Robert ^{[1
]}

Durrington, Hannah J. ^{[1
,2
]}

Venkateswaran, Rajamayier V. ^{[1
,3
]}

Cypel, Marcelo ^{[4
]}

Keshavjee, Shaf ^{[4
]}

Gibbs, Julie E. ^{[1
]}

Loudon, Andrew S. ^{[1
]}

Chow, Chung-Wai ^{[4
]}

Ray, David W. ^{[1
,5
,6
]}

Blaikley, John F. ^{[1
,3
]}

机构：

[1] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Manchester M13 9PL, Lancs, England

[2] Manchester Univ NHS Fdn Trust, Dept Resp Med, Manchester, Lancs, England

[3] Manchester Univ NHS Fdn Trust, Dept Cardiothorac Surg, Manchester, Lancs, England

[4] Univ Toronto, Toronto Gen Hosp, Univ Hlth Network, Toronto Lung Transplant Program, Toronto, ON, Canada

[5] John Radcliffe Hosp, NIHR Oxford Biomed Res Ctr, Oxford, England

[6] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England

来源：

THORAX | 2019年 / 74卷 / 04期

基金：

英国惠康基金;

关键词：

INTERNATIONAL-SOCIETY; HEART; TIME;

D O I：

10.1136/thoraxjnl-2018-212021

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The importance of circadian factors in managing patients is poorly understood. We present two retrospective cohort studies showing that lungs reperfused between 4 and 8 AM have a higher incidence (OR 1.12; 95% CI 1.03 to 1.21; p=0.01) of primary graft dysfunction (PGD) in the first 72 hours after transplantation. Cooling of the donor lung, occurring during organ preservation, shifts the donor circadian clock causing desynchrony with the recipient. The clock protein REV-ERBa directly regulates PGD biomarkers explaining this circadian regulation while also allowing them to be manipulated with synthetic REV-ERB ligands.

引用

页码：413 / 416

页数：4

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