When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

被引：60
作者：
Gonzalez-Quiroz, Matias [1 ,2 ,3 ,4 ,5 ]
Blondel, Alice [4 ,5 ]
Sagredo, Alfredo [1 ,2 ,3 ]
Hetz, Claudio [1 ,2 ,3 ,6 ]
Chevet, Eric [4 ,5 ]
Pedeux, Remy [4 ,5 ]
机构：
[1] Univ Chile, Fac Med, Biomed Neurosci Inst BNI, Santiago, Chile
[2] Univ Chile, Ctr Gerosci Brain Hlth & Metab GERO, Santiago, Chile
[3] Univ Chile, Inst Biomed Sci, Program Cellular & Mol Biol, Santiago, Chile
[4] Univ Rennes 1, Inst Natl Sante & Rech Med INSERM, Unite 1242, Chem Oncogenesis Stress & Signaling Lab, Rennes, France
[5] Ctr Lutte Canc Eugene Marquis, Rennes, France
[6] Buck Inst Res Aging, Novato, CA 94945 USA
来源：
TRENDS IN CELL BIOLOGY | 2020年 / 30卷 / 11期
基金：
欧盟地平线“2020”;
关键词：
UNFOLDED-PROTEIN-RESPONSE; STRAND BREAK REPAIR; MESSENGER-RNA; TUMOR-CELLS; STRESS; CANCER; APOPTOSIS; PERK; P53; SURVIVAL;
D O I：
10.1016/j.tcb.2020.09.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein response (UPR) and the DNA damage response (DDR). These adaptive mechanisms take place respectively in the endoplasmic reticulum (ER) and in the nucleus. UPR and DDR alterations are associated with aging and with pathologies such as degenerative diseases, metabolic and inflammatory disorders, and cancer. We discuss the emerging signaling crosstalk between UPR stress sensors and the DDR, as well as their involvement in cancer biology.
引用
收藏
页码：881 / 891
页数：11
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