Targeting NRF2-KEAP1 axis by Omega-3 fatty acids and their derivatives: Emerging opportunities against aging and diseases

被引：28

作者：

Davinelli, Sergio ^{[1
]}

Medoro, Alessandro ^{[1
]}

Intrieri, Mariano ^{[1
]}

Saso, Luciano ^{[2
]}

Scapagnini, Giovanni ^{[1
,5
]}

Kang, Jing X. ^{[3
,4
]}

机构：

[1] Univ Molise, Dept Med & Hlth Sci V Tiberio, Campobasso, Italy

[2] Sapienza Univ Rome, Dept Physiol & Pharmacol Vittorio Erspamer, Rome, Italy

[3] Massachusetts Gen Hosp, Dept Med, Lab Lipid Med & Technol, Boston, MA USA

[4] Harvard Med Sch, Boston, MA USA

[5] Univ Molise, Dept Med & Hlth Sci V Tiberio, Via De Sanctis Snc, Campobasso, Italy

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2022年 / 193卷

关键词：

Polyunsaturated fatty acids; NRF2; Aging; Inflammation; Oxidative stress; POLYUNSATURATED FATTY-ACIDS; TRANSCRIPTION FACTOR NRF2; CUL3-BASED E3 LIGASE; OXIDATIVE STRESS; MACULAR DEGENERATION; ANTIINFLAMMATORY MEDIATORS; PROTEASOMAL DEGRADATION; ANTIOXIDANT SYSTEMS; ALZHEIMERS-DISEASE; CELL ACTIVATION;

D O I：

10.1016/j.freeradbiomed.2022.11.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcription factor NRF2 and its endogenous inhibitor KEAP1 play a crucial role in the maintenance of cellular redox homeostasis by regulating the gene expression of diverse networks of antioxidant, anti-inflammatory, and detoxification enzymes. Therefore, activation of NRF2 provides cytoprotection against numerous pathologies, including age-related diseases. An age-associated loss of NRF2 function may be a key driving force behind the aging phenotype. Recently, numerous NRF2 inducers have been identified and some of them are promising candidates to restore NRF2 transcriptional activity during aging. Emerging evidence in-dicates that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and their electrophilic derivatives may trigger a protective response via NRF2 activation, rescuing or maintaining cellular redox homeostasis. In this review, we provide an overview of the NRF2-KEAP1 system and its dysregulation in aging cells. We also summarize current studies on the modulatory role of n-3 PUFAs as potential agents to prevent multiple chronic diseases and restore the age-related impairment of NRF2 function.

引用

页码：736 / 750

页数：15

共 187 条

[1] Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids [J].