Ethyl 6-acetylamino-6,7-dihydro-5H-dibenzo[a,c]cycloheptene-6-carboxylate

被引：9

作者：

Damodharan, L

Shamaladevi, N

Pattabhi, V

Behera, M

Kotha, S

机构：

[1] Univ Madras, Dept Crystallog & Biophys, Chennai 600025, Tamil Nadu, India

[2] Indian Inst Technol, Dept Chem, Powai 400076, Mumbai, India

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 2002年 / 58卷 / 05期

关键词：

D O I：

10.1107/S0108270102004687

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The title compound, C20H21NO3, is a derivative of Aib (alpha-aminoisobutyric acid) and is cyclized at the C-alpha position by biphenyl rings. The seven-membered ring possesses C2 symmetry. The C-alpha cyclization causes the backbone to assume a helical conformation in the crystal structure. The packing of the molecules is stabilized by intermolecular C-H...O, C-H...pi and N-H...O hydrogen bonds.

引用

收藏

页码：o266 / o267

页数：2

相关论文

共 22 条

[1] CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTER - COMPUTER-BASED SEARCH, RETRIEVAL, ANALYSIS AND DISPLAY OF INFORMATION [J].

ALLEN, FH ;

BELLARD, S ;

BRICE, MD ;

CARTWRIGHT, BA ;

DOUBLEDAY, A ;

HIGGS, H ;

HUMMELINK, T ;

HUMMELINKPETERS, BG ;

KENNARD, O ;

MOTHERWELL, WDS ;

RODGERS, JR ;

WATSON, DG .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1979, 35 (OCT) :2331-2339

[2] PREFERRED CONFORMATION OF PEPTIDES FROM C-ALPHA,ALPHA-SYMMETRICALLY DISUBSTITUTED GLYCINES - AROMATIC RESIDUES [J].

CRISMA, M ;

VALLE, G ;

BONORA, GM ;

TONIOLO, C ;

LELJ, F ;

BARONE, V ;

FRATERNALI, F ;

HARDY, PM ;

MAIA, HLS .

BIOPOLYMERS, 1991, 31 (06) :637-641

[3]

Desiraju G. R., 1989, DESIGN ORGANIC SOLID

[4]

*ENR NON, 1994, CAD 4 EXPRESS VERS 5

[5] ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI) [J].

Journal of Applied Crystallography, 1997, 30 (pt 5)

[6] Bip:: a Cα-tetrasubstituted, axially chiral α-amino acid.: Synthesis and conformational preference of model peptides [J].

Formaggio, F ;

Crisma, M ;

Toniolo, C ;

Tchertanov, L ;

Guilhem, J ;

Mazaleyrat, JP ;

Gaucher, A ;

Wakselman, M .

TETRAHEDRON, 2000, 56 (44) :8721-8734

[7]

HARMS K, 1995, XCAD4

[8] 3-AMINO-2H-AZIRINES - SYNTHONS FOR ALPHA,ALPHA-DISUBSTITUTED ALPHA-AMINO-ACIDS IN HETEROCYCLE AND PEPTIDE-SYNTHESIS [J].

HEIMGARTNER, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1991, 30 (03) :238-264

[9] STRUCTURAL CHARACTERISTICS OF ALPHA-HELICAL PEPTIDE MOLECULES CONTAINING AIB RESIDUES [J].

KARLE, IL ;

BALARAM, P .

BIOCHEMISTRY, 1990, 29 (29) :6747-6756

[10] Diels-Alder approach to tetralin-based constrained α-amino acid derivatives [J].

Kotha, S ;

Ganesh, T ;

Ghosh, AK .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (15) :1755-1757