Rabies vaccines: Current status and prospects for development

被引：7

作者：

Starodubova, E. S. ^{[1
]}

Preobrazhenskaia, O. V. ^{[1
]}

Kuzmenko, Y. V. ^{[1
]}

Latanova, A. A. ^{[1
]}

Yarygina, E. I. ^{[2
]}

Karpov, V. L. ^{[1
]}

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

[2] Skryabin Moscow State Acad Vet Med & Biotechnol, Moscow 109472, Russia

来源：

MOLECULAR BIOLOGY | 2015年 / 49卷 / 04期

关键词：

rabies; rabies vaccine; glycoprotein; ATTENUATED RECOMBINANT RABIES; PROTECTIVE IMMUNE-RESPONSE; DNA VACCINE; VIRUS GLYCOPROTEIN; EXPRESSION; MICE; IMMUNOGENICITY; EFFICACY; DOGS; STRATEGIES;

D O I：

10.1134/S0026893315040172

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rabies is an infectious disease among humans and animals that remains incurable, despite its longstanding research history. The only way to prevent the disease is prompt treatment, including vaccination as an obligatory component and administration of antirabies immunoglobulin as a supplement. Since the first antirabies vaccination performed in the 19th century, a large number of different rabies vaccines have been developed. Progress in molecular biology and biotechnology enabled the development of effective and safe technologies of vaccine production. Currently, new-generation vaccines are being developed based on recombinant rabies virus strains or on the production of an individual recombinant rabies antigen-glycoprotein (G protein), either as a component of nonpathogenic viruses, or in plants, or in the form of DNA vaccines. In this review, the main modern trends in the development of rabies vaccines have been discussed.

引用

页码：513 / 519

页数：7

共 59 条

[1] A New Rabies Vaccine Based on a Recombinant Orf Virus (Parapoxvirus) Expressing the Rabies Virus Glycoprotein [J].

Amann, Ralf ;

Rohde, Joerg ;

Wulle, Ulrich ;

Conlee, Douglas ;

Raue, Rudiger ;

Martinon, Olivier ;

Rziha, Hanns-Joachim .

JOURNAL OF VIROLOGY, 2013, 87 (03) :1618-1630

[2]

[Anonymous], 2012, world Journal of Vaccines

[3] High level expression of surface glycoprotein of rabies virus in tobacco leaves and its immunoprotective activity in mice [J].

Ashraf, S ;

Singh, PK ;

Yadav, DK ;

Shahnawaz, M ;

Mishra, S ;

Sawant, SV ;

Tuli, R .

JOURNAL OF BIOTECHNOLOGY, 2005, 119 (01) :1-14

[4]

Avdeeva Zh. I., 2009, TIKHOOKEANSKIY MED Z, V3, P19

[5] Field trials of a very potent rabies DNA vaccine which induced long lasting virus neutralizing antibodies and protection in dogs in experimental conditions [J].

Bahloul, C ;

Taieb, D ;

Diouani, MF ;

Ahmed, SBH ;

Chtourou, Y ;

B'chir, BI ;

Kharmachi, H ;

Dellagi, K .

VACCINE, 2006, 24 (08) :1063-1072

[6]

Briggs DJ, 2013, RABIES: SCIENTIFIC BASIS OF THE DISEASE AND ITS MANAGEMENT, 3RD EDITION, P497, DOI 10.1016/B978-0-12-396547-9.00013-4

[7] A Novel Rabies Vaccine Based on a Recombinant Parainfluenza Virus 5 Expressing Rabies Virus Glycoprotein [J].

Chen, Zhenhai ;

Zhou, Ming ;

Gao, Xiudan ;

Zhang, Guoqing ;

Ren, Guiping ;

Gnanadurai, Clement W. ;

Fu, Zhen F. ;

He, Biao .

JOURNAL OF VIROLOGY, 2013, 87 (06) :2986-2993

[8] Efficacy and bait acceptance of vaccinia vectored rabies glycoprotein vaccine in captive foxes (Vulpes vulpes), raccoon dogs (Nyctereutes procyonoides) and dogs (Canis familiaris) [J].

Cliquet, F. ;

Barrat, J. ;

Guiot, A. L. ;

Cael, N. ;

Boutrand, S. ;

Maki, J. ;

Schumacher, C. L. .

VACCINE, 2008, 26 (36) :4627-4638

[9]

Cruz ET, 2006, DEV BIOLOGICALS, V125, P221

[10] In vitro growth and stability of recombinant rabies viruses designed for vaccination of wildlife [J].

Dietzschold, ML ;

Faber, M ;

Mattis, JA ;

Pak, KY ;

Schnell, MJ ;

Dietzschold, B .

VACCINE, 2004, 23 (04) :518-524

← 1 2 3 4 5 6 →