Fulminant type 1 diabetes mellitus in Japanese children and adolescents: multi-institutional joint research of the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes

被引：9

作者：

Shiga, Kentaro ^{[1
,84
]}

Urakami, Tatsuhiko ^{[2
,75
]}

Suzuki, Junichi ^{[2
,75
]}

Igarashi, Yasuhiro ^{[3
,10
]}

Tajima, Hanako ^{[4
,74
]}

Amemiya, Shin ^{[5
,37
]}

Sugihara, Shigetaka ^{[6
,59
]}

Takahashi, Ikuko ^{[7
]}

Tanahashi, Yusuke ^{[8
]}

Matsuo, Kumihiro ^{[8
]}

Iwamoto, Jiro ^{[9
]}

Yatsuga, Shuichi ^{[9
]}

Endo, Akira ^{[11
]}

Takemoto, Koji ^{[12
]}

Hamada, Junpei ^{[12
]}

Ihara, Kenji ^{[13
]}

Ohki, Yukashi ^{[14
]}

Takaya, Ryuzo ^{[15
]}

Mochizuki, Takahiro ^{[15
]}

Kawamura, Tomoyuki ^{[16
]}

Horita, Yuko ^{[16
]}

Furujo, Mahoko ^{[17
]}

Inoue, Masaru ^{[18
]}

Hasegawa, Kosei ^{[19
]}

Adachi, Masanori ^{[20
]}

Okajima, Michiko ^{[21
]}

Shimura, Kazuhiro ^{[22
]}

Ohtsu, Shigeyuki ^{[23
]}

Kitsuda, Kazuteru ^{[23
]}

Ito, Yoshiya ^{[24
]}

Hori, Tomohiro ^{[25
]}

Ishii, Kanako ^{[26
]}

Kawada, Yasusada ^{[27
]}

Nakajima, Hisakazu ^{[28
]}

Ito, Ikuyo ^{[28
]}

Nakamura, Kimitoshi ^{[29
]}

Miyagawa, Shinichiro ^{[30
]}

Jinno, Kazuhiko ^{[31
]}

Horikawa, Reiko ^{[32
]}

Yoshida, Tomoko ^{[32
]}

Fukami, Maki ^{[32
]}

Mori, Testuo ^{[33
]}

Kobayashi, Kisyo ^{[34
]}

Konda, Susumu ^{[35
]}

Sasaki, Nozomu ^{[36
]}

Kikuchi, Toru ^{[37
]}

Musha, Ikuma ^{[37
]}

Aizu, Katsuya ^{[38
]}

Mochizuki, Hiroshi ^{[38
]}

Hotsubo, Tomoyuki ^{[39
]}

机构：

[1] Yokohama City Univ, Med Ctr, Childrens Med Ctr, Kanagawa 2320024, Japan

[2] Nihon Univ, Sch Med, Dept Pediat, Tokyo 1018309, Japan

[3] Igarashi Childrens Clin, Miyagi 9813203, Japan

[4] Nippon Med Sch, Dept Pediat, Tokyo 1138602, Japan

[5] Saitama Med Univ, Dept Pediat, Saitama 3500495, Japan

[6] Tokyo Womens Med Univ, Dept Pediat, Med Ctr East, Tokyo 1168567, Japan

[7] Akita Univ, Sch Med, Akita, Japan

[8] Asahikawa Med Univ, Asahikawa, Hokkaido, Japan

[9] Asoiizuka Hosp, Iizuka, Fukuoka, Japan

[10] Igarashi Childrens Clin, Sendai, Miyagi, Japan

[11] Iwata City Hosp, Iwata, Japan

[12] Ehime Univ, Sch Med, Matsuyama, Ehime, Japan

[13] Oita Univ, Fac Med, Sch Med, Oita, Japan

[14] Pediat Endocrinol & Metab Clin, Osaka, Japan

[15] Osaka Med Coll, Takatsuki, Osaka, Japan

[16] Osaka City Univ, Sch Med, Osaka, Japan

[17] Okayama Med Ctr, Okayama, Japan

[18] Okayama Red Cross Gen Hosp, Okayama, Japan

[19] Okayama Univ, Sch Med, Okayama, Japan

[20] Kanagawa Childrens Med Ctr, Yokohama, Kanagawa, Japan

[21] Kanazawa Univ, Sch Med, Kanazawa, Ishikawa, Japan

[22] Kawasaki Municipal Hosp, Kawasaki, Kanagawa, Japan

[23] Kitasato Univ, Sch Med, Tokyo, Japan

[24] Kitami Red Cross Hosp, Kitami, Hokkaido, Japan

[25] Gifu Univ Hosp, Gifu, Japan

[26] Kyushu Univ, Sch Med, Fukuoka, Fukuoka, Japan

[27] Kyushu Rosai Hosp, Kitakyushu, Fukuoka, Japan

[28] Kyoto Prefectural Univ Med, Kyoto, Japan

[29] Kumamoto Univ, Sch Med, Kumamoto, Japan

[30] Natl Hosp Org Kure Med Ctr, Kure, Japan

[31] Hiroshima Prefectural Hosp, Hiroshima, Japan

[32] Natl Ctr Child Hlth & Dev, Tokyo, Japan

[33] Shinshu Ueda Med Ctr, Ueda, Nagano, Japan

[34] Kobayashi Kids Clin, Kumagaya, Saitama, Japan

[35] Konda Childrens Clin, Tokyo, Japan

[36] Saitama Med Univ, Kawagoe Clin, Kawagoe, Saitama, Japan

[37] Saitama Med Univ, Kawagoe, Saitama, Japan

[38] Saitama Childrens Med Ctr, Saitama, Japan

[39] Sapporo Pediat Endocrinol Clin, Sapporo, Hokkaido, Japan

[40] Sapporo Factory Kids Clin, Sapporo, Hokkaido, Japan

[41] Univ Occupat & Environm Hlth, Kitakyushu, Fukuoka, Japan

[42] Sanno Hosp, Tokyo, Japan

[43] JR Sendai Hosp, Sendai, Miyagi, Japan

[44] Shiga Med Sch, Otsu, Shiga, Japan

[45] Shikoku Med Ctr Children & Adults, Zentsuji, Japan

[46] Juntendo Univ Med, Tokyo, Japan

[47] Shinshu Univ Hosp, Matsumoto, Nagano, Japan

[48] Seitoku Univ, Matsudo, Chiba, Japan

[49] Seitoku Univ, Jr Coll, Matsudo, Chiba, Japan

[50] St Marianna Univ, Sch Med, Kawasaki, Kanagawa, Japan

来源：

ENDOCRINE JOURNAL | 2018年 / 65卷 / 08期

关键词：

Fulminant type 1 diabetes mellitus; Pediatric-onset diabetes mellitus; Child; Adolescent; NATIONWIDE SURVEY; DIAGNOSTIC-CRITERIA; RAPID-ONSET; HEMOGLOBIN; SOCIETY; COMMITTEE; PANCREAS; GENOTYPE; SUBTYPE;

D O I：

10.1507/endocrj.EJ18-0029

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fulminant type 1 diabetes mellitus (FT1DM) is a subtype of type 1 diabetes mellitus characterized by a remarkably abrupt onset. In Japan, FT1DM accounts for approximately 20% of acute-onset adult type 1 diabetes mellitus cases; however, reports of pediatric-onset FT1DM are rare. We aimed to determine the frequency and clinical characteristics of FT1DM in Japanese children and adolescents by conducting a 2-phase questionnaire survey among the members of the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT) regarding their clinical experience with FT1DM. Responses were obtained from 54 of the 79 participating hospitals (68.4%). Of these, 8 hospitals managed a total of 15 pediatric patients with FT1DM (4 patients in each of 2 hospitals, 2 patients in 1 hospital, and 1 patient in each of 5 hospitals). The distribution of patient age was biphasic, with peaks in children younger than 5 years and older than 8 years of age. The clinical characteristics of FT1DM in this population (such as the duration from onset of symptoms to diagnosis, severity of symptoms, preceding flu-like episodes, and abnormal laboratory data) did not differ from those of patients with adult-onset FT1DM. The frequency of pediatric-onset FT1DM is low compared with that of adult-onset FT1DM. The genetic background and susceptibility patterns of pediatric patients with FT1DM may differ from those typical of adults with FT1DM, but both age groups share similar clinical characteristics.

引用

页码：795 / 803

页数：9

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