Antibacterial activity of components from Lomatium californicum

被引：33

作者：

Chou, SC

Everngam, MC

Sturtz, G

Beck, JJ ^{[1
]}

机构：

[1] Sweet Briar Coll, Dept Chem, Sweet Briar, VA 24595 USA

[2] Wildlife Int Ltd, Easton, MD 21601 USA

[3] AromaGen, Albany, OR 97321 USA

来源：

PHYTOTHERAPY RESEARCH | 2006年 / 20卷 / 02期

关键词：

apiaceae; Lomatium; falcarindiol; coniferyl ferulate; ferulic acid; ligustilide; senkyunolide; neocnidilide; antibacterial;

D O I：

10.1002/ptr.1828

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The isolation, characterization and bioactivity testing of compounds from Lomatium californicum (Nutt.) are described. Ethyl acetate and hexane extracts of the roots of L. californicum were subjected to vacuum liquid chromatography (VLC), flash column chromatography (FCC) and separation by normal- and reverse-phase high-performance liquid chromatography (HPLC). Six compounds were isolated successfully and characterized by 1D and 2D nuclear magnetic resonance (NMR) experimentation. The bioactivity of the known compounds (+)-falcarindiol, coniferyl ferulate, ferulic acid and (Z)-ligustilide were confirmed against the Gram-positive bacteria Bacillus subtilis and Staphylococcus aureus. The known compounds senkyunolide I and trans-neocnidilide were also isolated but in too small a quantity for similar testing. Copyright (c) 2006 John Wiley & Sons, Ltd.

引用

页码：153 / 156

页数：4

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