Reduced delta power and synchrony and increased gamma power during the P3 time window in schizophrenia

被引：12

作者：

Donkers, Franc C. L. ^{[1
,2
]}

Englander, Zoe A. ^{[3
]}

Tiesinga, Paul H. E. ^{[4
,5
]}

Cleary, Katherine M. ^{[1
]}

Gu, Hongbin ^{[1
]}

Belger, Aysenil ^{[1
,3
]}

机构：

[1] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA

[2] Tilburg Univ, Dept Psychol, NL-5000 LE Tilburg, Netherlands

[3] Duke Univ, Brain Imaging & Anal Ctr, Durham, NC USA

[4] Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC 27599 USA

[5] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Neuroinformat, NL-6525 ED Nijmegen, Netherlands

来源：

SCHIZOPHRENIA RESEARCH | 2013年 / 150卷 / 01期

关键词：

Schizophrenia; Wavelet analysis; Time-frequency analysis; Delta frequency band; Theta frequency band; Gamma frequency band; P3;

D O I：

10.1016/j.schres.2013.07.050

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Event-related potential studies in schizophrenia have demonstrated amplitude reduction of the P3 in oddball tasks. The P3 has been linked to attention and memory brain functions. Methods: In 24 schizophrenia patients and 28 control subjects, wavelet transform was used to reveal event-related modulations of the EEG signal during target trials in delta, theta, alpha, beta, and gamma frequency bands. Results: Patients showed reductions in P3 amplitude accompanied by reduced low frequency delta-theta and increased beta-gamma band EEG activity. Conclusions: These results indicate abnormalities in the synchronization and/or efficiency of neural processes involved in memory and attention networks in schizophrenia. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：266 / 268

页数：3

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