New excitation functions for proton induced reactions on natural gadolinium up to 70 MeV with focus on 149Tb production

被引：16
作者：
Formento-Cavaier, R. [1 ,2 ,3 ]
Haddad, F. [2 ,3 ]
Alliot, C. [2 ,4 ]
Sounalet, T. [2 ,3 ]
Zahi, I [1 ]
机构：
[1] Adv Accelerator Applicat, 20 Rue Diesel, F-01630 St Genis Pouilly, France
[2] GIP Arronax, 1 Rue Aronnax, F-44800 St Herblain, France
[3] Univ Nantes, IMT Atlantique, CNRS IN2P3, Subatech, CS 20722, F-44307 Nantes, France
[4] INSERM, U892, 1 Quai Moncousu, Nantes 44, France
来源：
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 2020年 / 478卷 / 478期
基金：
欧盟地平线“2020”;
关键词：
149Tb; Theranostics; Terbium; Cross section; Radionuclides production; MEDICAL ISOTOPES; CROSS-SECTIONS;
D O I：
10.1016/j.nimb.2020.06.029
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
Terbium is one of the most interesting elements for new potential theranostics applications. Indeed, the physical properties of four of its radionuclides (Tb-149, Tb-152, Tb-155, Tb-161) allow their use in each main applications of nuclear medicine. Tb-149 is the lowest mass alpha emitter with suitable physical properties for receptor-targeted alpha therapy (TAT), and the only one among the radiolanthanides. Currently Tb-149 is only produced through spallation reactions induced by high-energy proton beam coupled with mass separation to obtain suitable purity. The aim of the present work is to investigate the production of Tb-149 using commercial cyclotrons by irradiation of natural gadolinium target. New excitation functions for proton-induced nuclear reactions on natural gadolinium have been measured. Our results extend current knowledge up to 70 MeV and are in good agreement with existing data at low energy. From this new set of data, production yield estimations are calculated and discussed.
引用
收藏
页码：174 / 181
页数：8
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