Depth resolved detection of lipid using spectroscopic optical coherence tomography

被引：63

作者：

Fleming, Christine P. ^{[1
]}

Eckert, Jocelyn ^{[2
]}

Halpern, Elkan F. ^{[3
]}

Gardecki, Joseph A. ^{[2
]}

Tearney, Guillermo J. ^{[2
,4
]}

机构：

[1] Columbia Univ, Dept Elect Engn, New York, NY 10027 USA

[2] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Div Radiol, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2013年 / 4卷 / 08期

基金：

美国国家卫生研究院;

关键词：

ATHEROSCLEROTIC PLAQUES; RAMAN-SPECTROSCOPY; SCATTERING MEDIA; ABSORPTION; CHOLESTEROL; ATTENUATION; MICROSCOPY; MORPHOLOGY; PROFILES; COLLAGEN;

D O I：

10.1364/BOE.4.001269

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Optical frequency domain imaging (OFDI) can identify key components related to plaque vulnerability but can suffer from artifacts that could prevent accurate identification of lipid rich regions. In this paper, we present a model of depth resolved spectral analysis of OFDI data for improved detection of lipid. A quadratic Discriminant analysis model was developed based on phantom compositions known chemical mixtures and applied to a tissue phantom of a lipid-rich plaque. We demonstrate that a combined spectral and attenuation model can be used to predict the presence of lipid in OFDI images. (C) 2013 Optical Society of America

引用

页码：1269 / 1284

页数：16

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