Lipase Inhibitors for Obesity: A Review

被引:281
作者
Liu, Tian-Tian [1 ]
Liu, Xiao-Tian [1 ]
Chen, Qing-Xi [1 ]
Shi, Yan [1 ]
机构
[1] Xiamen Univ, Sch Life Sci, Key Lab, Minist Educ Coastal & Wetland Ecosyst, Xiamen 361005, Peoples R China
关键词
obesity; lipid metabolism; lipase inhibitor; natural product; CURCUMA-LONGA L; PANCREATIC LIPASE; ALPHA-AMYLASE; FATTY-ACID; EXTRACELLULAR LIPASE; INSULIN-RESISTANCE; GASTRIC LIPASE; IN-VITRO; ORLISTAT; EXTRACT;
D O I
10.1016/j.biopha.2020.110314
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
With the rapid increase in the population of obese individuals, obesity has become a global problem. Many kinds of chronic metabolic diseases easily caused by obesity have received increasing attention from researchers. People are also striving to find various safe and effective treatment methods as well as anti-obesity medicines. Pancreatic lipase (PL) inhibitors have received substantial attention from researchers in recent years, and PL inhibitors from natural products have attracted much attention due to their structural diversity, low toxicity and wide range of sources. They have been used in the intestinal tract, blood, and the central nervous system with no side effects, and these advantages could lead to a new generation of diet pills or health care products with great development potential. This article is mainly aimed at discussing the research of obesity drug treatment with PL inhibitors and offers a brief review of related properties and the use of PL inhibitors in the field of weight loss.
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页数:9
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