Stable Preformed Chiral Palladium Catalysts for the One-Pot Asymmetric Reductive Amination of Ketones

被引：97

作者：

Rubio-Perez, Laura ^{[1
]}

Perez-Flores, F. Javier ^{[1
]}

Sharma, Pankaj ^{[1
]}

Velasco, Luis ^{[1
]}

Cabrera, Armando ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 02期

关键词：

TRANSFER HYDROGENATION; ENANTIOSELECTIVE SYNTHESIS; LIGANDS; IMINES; HYDROSILYLATION; ALDEHYDES;

D O I：

10.1021/ol802336m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asymmetric reductive amination of various carbonyl compounds, leading to chiral amines in very good yields with high enantioselectivities (<99% ee), is reported.

引用

页码：265 / 268

页数：4

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