Cyclic estradiol treatment phasically potentiates endogenous cholecystokinin's satiating action in ovariectomized rats

被引：55

作者：

Asarian, L ^{[1
]}

Geary, N ^{[1
]}

机构：

[1] Cornell Univ, Joan & Sandford I Weill Med Coll, New York Presbyterian Hosp,Dept Psychiat, Westchester Div,Res Lab, White Plains, NY 10605 USA

来源：

PEPTIDES | 1999年 / 20卷 / 04期

关键词：

estrus cycle; ovariectomy; meal size; devazepide; feeding;

D O I：

10.1016/S0196-9781(99)00024-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of ovarian cycling and of exogenous estradiol on the cholecystokinin (CCK) satiety-signalling system was investigated in intact and ovariectomized Long-Evans rats, respectively. Intraperitoneal injection of 1 mg/kg devazepide, the most potent and selective CCK, receptor antagonist, increased test meal size during estrus, but not during diestrus, confirming the influence of hypothalamic-pituitary-gonadal function on CCK satiety in intact rats. Devazepide was then tested in ovariectomized rats that received chronic cyclic estradiol (2 mu g estradiol benzoate on Tuesday and Wednesday each week) or oil treatment. Devazepide did not increase meal size in estradiol-treated rats on Tuesday, prior to estradiol treatment, compared to oil-treated rats, but did selectively increase meal size on Friday, late in the estradiol replacement cycle, compared to Tuesday, early in the cycle. These results suggest that a phasic potentiation of the endogenous CCK satiety-signalling system is part of the mechanism for the decrease in meal size in female rats during estrus. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：445 / 450

页数：6

共 32 条

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