Infrequent false positive [18F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques

被引：18

作者：

Ikonomovic, Milos D. ^{[1
,2
,3
]}

Fantoni, Enrico R. ^{[4
]}

Farrar, Gill ^{[4
]}

Salloway, Stephen ^{[5
]}

机构：

[1] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA

[3] VA Pittsburgh Healthcare Syst, Geriatr Res Educ & Clin Ctr, Pittsburgh, PA 15213 USA

[4] GE Healthcare Life Sci, Amersham, England

[5] Butler Hosp Providence, Neurol & Memory & Aging Program, Providence, RI USA

来源：

ALZHEIMERS RESEARCH & THERAPY | 2018年 / 10卷

关键词：

Flutemetamol; Amyloid; PET; Diffuse plaques; Neuritic plaques; Alzheimer's disease; ALZHEIMER-DISEASE; DIAGNOSTIC-CRITERIA; NATIONAL INSTITUTE; DEPOSITION; VALIDATION; STRIATUM; BRAIN;

D O I：

10.1186/s13195-018-0387-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The performance of [F-18]flutemetamol amyloid PET against histopathological standards of truth was the subject of our recent article in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (2017; 9: 25-34). Main body: This viewpoint article addresses infrequently observed discordance between visual [F-18]flutemetamol PET image readings and histopathology based solely on neuritic plaque assessment by CERAD criteria, which is resolved by assessing both neuritic and diffuse plaques and/or brain atrophy. Conclusion: [F-18]flutemetamol PET signal corresponds predominantly to neuritic plaque pathology but is also influenced by the presence of diffuse plaques. This could allow for detection of diffuse amyloid deposits in the early stages of AD dementia, particularly in the striatum where diffuse amyloid is most commonly observed.

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