A genome-wide association study of late-onset Alzheimer's disease in a Japanese population

被引：30

作者：

Hirano, Atsushi ^{[1
,2
]}

Ohara, Tomoyuki ^{[1
,3
,4
]}

Takahashi, Atsushi ^{[1
]}

Aoki, Masayuki ^{[1
]}

Fuyuno, Yuta ^{[1
,2
]}

Ashikawa, Kyota ^{[1
]}

Morihara, Takashi ^{[5
]}

Takeda, Masatoshi ^{[5
]}

Kamino, Kouzin ^{[6
]}

Oshima, Etsuko ^{[7
]}

Okahisa, Yuko ^{[7
]}

Shibata, Nobuto ^{[8
]}

Arai, Heii ^{[8
]}

Akatsu, Hiroyasu ^{[9
]}

Ikeda, Masashi ^{[10
]}

Iwata, Nakao ^{[10
]}

Ninomiya, Toshiharu ^{[4
]}

Monji, Akira ^{[11
]}

Kitazono, Takanari ^{[2
]}

Kiyohara, Yutaka ^{[4
]}

Kubo, Michiaki ^{[1
]}

Kanba, Shigenobu ^{[3
]}

机构：

[1] RIKEN Yokohama Inst, Ctr Integrat Med Sci, Lab Genotyping Dev, Yokohama, Kanagawa 2300045, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka 812, Japan

[3] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka 812, Japan

[4] Kyushu Univ, Grad Sch Med Sci, Dept Environm Med, Fukuoka 812, Japan

[5] Osaka Univ, Grad Sch Med, Dept Psychiat, Osaka, Japan

[6] Natl Hosp Org Yamato Mental Med Ctr, Nara, Japan

[7] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat, Okayama 7008530, Japan

[8] Juntendo Univ, Sch Med, Dept Psychiat, Tokyo 113, Japan

[9] Fukushimura Hosp, Choju Med Inst, Fukushima, Japan

[10] Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi, Japan

[11] Saga Univ, Fac Med, Dept Psychiat, Saga 840, Japan

来源：

PSYCHIATRIC GENETICS | 2015年 / 25卷 / 04期

关键词：

CNTNAP2; genome-wide association study; Japanese; late-onset Alzheimer's disease; NEUREXIN SUPERFAMILY; IDENTIFIES VARIANTS; MISSENSE MUTATIONS; COMMON VARIANTS; GENE; CNTNAP2; AUTISM; CONTACTIN-ASSOCIATED-PROTEIN-LIKE-2; PREVALENCE; DISORDERS;

D O I：

10.1097/YPG.0000000000000090

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

ObjectiveAlthough a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations.DesignTo discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by APOE-epsilon 4 status to eliminate the established effect of APOE region.ResultsOur data indicated that 18p11.32 (rs1992269, P=9.77x10(-7)), CNTNAP2 (rs802571, P=1.26x10(-6)), and 12q24.23 (rs11613092, P=6.85x10(-6)) were suggestive loci for susceptibility to LOAD.ConclusionWe identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective.

引用

页码：139 / 146

页数：8

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