Loss of peroxisome function triggers necrosis

被引：47

作者：

Jungwirth, Helmut ^{[1
]}

Ring, Julia ^{[1
]}

Mayer, Tanja ^{[1
]}

Schauer, Alexandra ^{[1
]}

Buettner, Sabrina ^{[1
]}

Eisenberg, Tobias ^{[1
]}

Carmona-Gutierrez, Didac ^{[1
]}

Kuchler, Karl ^{[2
]}

Madeo, Frank ^{[1
]}

机构：

[1] Graz Univ, IMB, A-8010 Graz, Austria

[2] Med Univ Vienna, Max F Perutz Labs, Christian Doppler Lab Infect Biol, A-1030 Vienna, Austria

来源：

FEBS LETTERS | 2008年 / 582卷 / 19期

基金：

奥地利科学基金会;

关键词：

peroxins; PEX6; acetic acid; stationary phase; necrosis;

D O I：

10.1016/j.febslet.2008.07.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Disturbance of peroxisome function can lead to various degenerative diseases during ageing. Here, we show that in yeast deletion of PEX6, encoding a protein involved in a key step of peroxisomal protein import, results in an increased accumulation of reactive oxygen species and an enhanced loss of viability upon acetic acid treatment and during early stationary phase. Cell death of ageing-like yeast cells lacking PEX6 does not depend on the apoptotic key players Yca1p and Aif1p, but instead shows markers of necrosis. Thus, we conclude that loss of peroxisomal function leads to a form of necrotic cell death. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2882 / 2886

页数：5

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