Stereotactic body radiation therapy for locally recurrent, previously irradiated nonsquamous cell cancers of the head and neck

Background Stereotactic body radiotherapy (SBRT) has emerged as a promising salvage strategy for patients with recurrent, previously irradiated head and neck cancer; however, data are limited predominantly to squamous cell carcinomas. Herein, we report the efficacy of SBRT in recurrent, nonsquamous cell cancers of the head and neck (NSCHNs). Methods In all, 34 patients with pathologically proven NSCHN were reirradiated with SBRT to a median dose of 40 Gy in 5 fractions (interquartile range, 3044 Gy). Toxicity and quality of life were followed prospectively. Results Median follow-up was 10 months (absolute range, 055 months). The 6-month/1-year local control rate was 77/59%, with a 6-month/1-year overall survival of 76/59%. Local control was significantly improved for tumors <25 mL (p = .030). Acute/late grade 3 toxicity was 15/6%, with no grade 45 toxicity. Conclusions SBRT for previously irradiated, locally recurrent NSCHN provides promising local control, especially for tumors <25 mL, with minimal toxicity. The optimal dose for larger tumors remains to be defined. (c) 2011 Wiley Periodicals, Inc. Head Neck, 2012