Facially-selective thymine-thymine photodimerization in TTT triads

被引：1

作者：

Neelakandan, Prakash P. ^{[1
]}

Pan, Zhengzheng ^{[1
]}

Hariharan, Mahesh ^{[1
,2
]}

Lewis, Frederick D. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[2] Indian Inst Sci Educ & Res Thiruvananthapuram, Sch Chem, Trivandrum 695016, Kerala, India

来源：

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2012年 / 11卷 / 06期

关键词：

DNA; CONFORMATION; DIMERIZATION; DYNAMICS; LESIONS; YIELDS; LIGHT;

D O I：

10.1039/c2pp25089f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Irradiation of alkane-linked DNA hairpins possessing TTT steps with flanking purine bases yields products identified as the cis-syn (2 + 2) dimers formed between the central thymine and its 3'- and 5'-neighbors. Selective formation of the 3'-dimer is attributed to ground state conformational effects and electron transfer quenching by purine bases.

引用

页码：889 / 892

页数：4

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