Nucleotide receptor signalling and the generation of reactive oxygen species

被引:38
作者
Guerra, Alma N. [1 ]
Gavala, Monica L. [1 ]
Chung, Hun Sun [1 ]
Bertics, Paul J. [1 ]
机构
[1] Univ Wisconsin, Sch Med, Dept Biomol Chem, Madison, WI 53706 USA
基金
美国国家卫生研究院;
关键词
extracellular nucleotides; NADPH oxidases; nitric oxide synthases; purinergic receptors; reactive oxygen species;
D O I
10.1007/s11302-006-9035-x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Elevated levels of extracellular nucleotides are present at sites of inflammation, platelet degranulation and cellular damage or lysis. These extracellular nucleotides can lead to the activation of purinergic (nucleotide) receptors on various leukocytes, including monocytes, macrophages, eosinophils, and neutrophils. In turn, nucleotide receptor activation has been linked to increased cellular production and release of multiple inflammatory mediators, including superoxide anion, nitric oxide and other reactive oxygen species (ROS). In the present review, we will summarize the evidence that extracellular nucleotides can facilitate the generation of multiple ROS by leukocytes. In addition, we will discuss several potential mechanisms by which nucleotide-enhanced ROS production may occur. Delineation of these mechanisms is important for understanding the processes associated with nucleotide-induced antimicrobial activities, cell signalling, apoptosis, and pathology.
引用
收藏
页码:39 / 51
页数:13
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