Role of VEGF gene variability in longevity: A lesson from the Italian population

被引：10

作者：

Del Bo, Roberto ^{[1
]}

Ghezzi, Serena ^{[1
]}

Scarlato, Marina ^{[1
]}

Albani, Diego ^{[2
]}

Galimberti, Daniela ^{[1
]}

Lucca, Ugo ^{[2
]}

Tettamanti, Mauro ^{[2
]}

Scarpini, Elio ^{[1
]}

Forloni, Gianluigi ^{[2
]}

Bresolin, Nereo ^{[1
,3
]}

Comi, Giacomo Pietro ^{[1
]}

机构：

[1] Univ Milan, IRCCS Fdn, Osped Maggiore Policlin Mangiagalli & Regina Elen, Dept Neurol Sci,Dino Ferrari Ctr, I-20122 Milan, Italy

[2] Ist Ric Farmacol Mario Negri, Dept Neurosci, Milan, Italy

[3] Assoc Nostra Famiglia, IRCCS E Medea, Bosisio Parini, Lecco, Italy

来源：

NEUROBIOLOGY OF AGING | 2008年 / 29卷 / 12期

关键词：

Aging; Vascular endothelial growth factor; Genetic risk factor; Longevity;

D O I：

10.1016/j.neurobiolaging.2007.05.003

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Vascular endothelial growth factor (VEGF) gene polymorphisms have been associated with an increased risk of developing a wide variety of disorders from diabetes to neurodegenerative diseases suggesting functions not confined to its vascular effects originally described. Based on the VEGF protective roles undisclosed in pathological conditions', we evaluate whether VEGF variability might be a determinant also for longevity. Four polymorphisms (-2578C/A, -1190G/A, -1154G/A and -634G/C) within the VEGF gene promoter region it] 490 unrelated Italian healthy subjects have been analysed. Significant changes of allele, genotype (-2578/AA versus -2578/CC: OR=2.08, p = 0.007; -1190/AA versus -1190/GG: OR = 2.01, p = 0.011) and haplotype (AAGG: 10.4% versus 14.9%, p = 0.03) frequency distributions were observed between young/elderly (25-84 years old) and long-lived (85-99 years old) subjects. These results suggest that VEGF gene variability can be inserted among the genetic factors influencing the lifespan. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1917 / 1922

页数：6

共 27 条

[1] Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 [J].

Baker, Matt ;

Mackenzie, Ian R. ;

Pickering-Brown, Stuart M. ;

Gass, Jennifer ;

Rademakers, Rosa ;

Lindholm, Caroline ;

Snowden, Julie ;

Adamson, Jennifer ;

Sadovnick, A. Dessa ;

Rollinson, Sara ;

Cannon, Ashley ;

Dwosh, Emily ;

Neary, David ;

Melquist, Stacey ;

Richardson, Anna ;

Dickson, Dennis ;

Berger, Zdenek ;

Eriksen, Jason ;

Robinson, Todd ;

Zehr, Cynthia ;

Dickey, Chad A. ;

Crook, Richard ;

McGowan, Eileen ;

Mann, David ;

Boeve, Bradley ;

Feldman, Howard ;

Hutton, Mike .

NATURE, 2006, 442 (7105) :916-919

[2] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[3] Angiogenesis in health and disease [J].

Carmeliet, P .

NATURE MEDICINE, 2003, 9 (06) :653-660

[4] VEGF gene and phenotype relation with Alzheimer's disease and mild cognitive impairment [J].

Chiappelli, Martina ;

Borroni, Barbara ;

Archetti, Silvana ;

Calabrese, Elena ;

Corsi, Massimiliano M. ;

Franceschi, Massimo ;

Padovani, Alessandro ;

Licastro, Federico .

REJUVENATION RESEARCH, 2006, 9 (04) :485-493

[5] The quest for genetic determinants of human longevity: challenges and insights [J].

Christensen, Kaare ;

Johnson, Thomas E. ;

Vaupel, James W. .

NATURE REVIEWS GENETICS, 2006, 7 (06) :436-448

[6] Vascular endothelial growth factor gene variability is associated with increased risk for AD [J].

Del Bo, R ;

Scarlato, M ;

Ghezzi, S ;

Boneschi, FM ;

Fenoglio, C ;

Galbiati, S ;

Virgilio, R ;

Galimberti, D ;

Galimberti, G ;

Crimi, M ;

Ferrarese, C ;

Scarpini, E ;

Bresolin, N ;

Comi, GP .

ANNALS OF NEUROLOGY, 2005, 57 (03) :373-380

[7] VEGF gene variability and type 1 diabetes:: evidence for a protective role [J].

Del Bo, R ;

Scarlato, M ;

Ghezzi, S ;

Maestroni, A ;

Sjölind, L ;

Forsblom, C ;

Wessman, M ;

Groop, PH ;

Comi, GP ;

Bresolin, N ;

Luzi, L ;

Zerbini, G .

IMMUNOGENETICS, 2006, 58 (2-3) :107-112

[8] Absence of angiogenic genes modification in Italian ALS patients [J].

Del Bo, Roberto ;

Scarlato, Marina ;

Ghezzi, Serena ;

Martinelli-Boneschi, Filippo ;

Corti, Stefania ;

Locatelli, Federica ;

Santoro, Domenico ;

Prelle, Alessandro ;

Briani, Chiara ;

Nardini, Martina ;

Siciliano, Gabriele ;

Mancuso, Michelangelo ;

Murri, Luigi ;

Bresolin, Nereo ;

Comi, Giacomo Pietro .

NEUROBIOLOGY OF AGING, 2008, 29 (02) :314-316

[9] The apolipoprotein E epsilon 4 allele causes a faster decline of cognitive performances in Down's syndrome subjects [J].

DelBo, R ;

Comi, GP ;

Bresolin, N ;

Castelli, E ;

Conti, E ;

Degiuli, A ;

Ausenda, CD ;

Scarlato, G .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1997, 145 (01) :87-91

[10] Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALS [J].

Fernandez-Santiago, R. ;

Sharma, M. ;

Mueller, J. C. ;

Gohlke, H. ;

Illig, T. ;

Anneser, J. ;

Munch, C. ;

Ludolph, A. ;

Kamm, C. ;

Gasser, T. .

NEUROLOGY, 2006, 66 (12) :1929-1931

← 1 2 3 →