Beneficial Effects of Ocimum gratissimum Aqueous Extract on Rats with CCl4-Induced Acute Liver Injury

被引：17

作者：

Chiu, Chun-Ching ^{[5
,6
,7
]}

Huang, Chih-Yang ^{[8
,9
,10
]}

Chen, Tzy-Yen ^{[11
,12
]}

Kao, Shao-Hsuan ^{[1
,2
]}

Liu, Jer-Yuh ^{[3
]}

Wang, Yi-Wen ^{[1
]}

Tzang, Bor-Show ^{[1
,2
,4
]}

Hsu, Tsai-Ching ^{[2
,5
]}

机构：

[1] Chung Shan Med Univ, Inst Biochem & Biotechnol, Taichung 40201, Taiwan

[2] Chung Shan Med Univ Hosp, Clin Lab, Taichung 40201, Taiwan

[3] China Med Univ Hosp, Ctr Mol Med, Taichung 40402, Taiwan

[4] Chung Shan Med Univ, Sch Med, Dept Biochem, Taichung 40201, Taiwan

[5] Chung Shan Med Univ, Inst Microbiol & Immunol, Taichung 40201, Taiwan

[6] Chunghua Christian Hosp, Dept Neurol, Chunghua 500, Taiwan

[7] Chunghua Christian Hosp, Dept Med Intens Care Unit, Chunghua 500, Taiwan

[8] China Med Univ, Grad Inst Chinese Med Sci, Taichung 40402, Taiwan

[9] China Med Univ, Inst Basic Med Sci, Taichung 40402, Taiwan

[10] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 41354, Taiwan

[11] Chung Shan Med Univ Hosp, Dept Internal Med, Taichung 40201, Taiwan

[12] Chung Shan Med Univ, Inst Med, Taichung 40201, Taiwan

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2012年 / 2012卷

关键词：

CARBON-TETRACHLORIDE; MATRIX METALLOPROTEINASES; EXPRESSION; HEPATOTOXICITY; FIBROSIS; SANCTUM; REPAIR; ENHANCEMENT; INDUCTION; SILYMARIN;

D O I：

10.1155/2012/736752

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Ocimum gratissimum (OG) is known as a food spice and traditional herb, which has been recommended for the treatment of various diseases. To investigate the hepatoprotective effect of OG aqueous extract (OGAE), male Wistar rats challenged by carbon tetrachloride (CCl4) were used as the animal model of chronic hepatic injury. Significantly increased serum catalase and DPPH levels were detected in CCl4-administrated rats that were treated with OGAE or silymarin as compared to those rats that were treated with saline or CCl4. In contrast, significantly decreased stress proteins including HSP70 and iNOS were observed in livers of CCl4-administrated rats that were treated with OGAE or sylimarin as compared to those rats that were treated with saline or CCl4. Moreover, significant decreases of MMP-9/MMP-2 ratio, uPA, phosphorylated ERK (p-ERK) and NF-kappa B (p-P65) were detected in livers of CCl4-administrated rats that were treated with OGAE or sylimarin as compared to those rats that were treated with saline or CCl4. These findings imply that OGAE can efficiently inhibit CCl4-induced liver injuries in rats and may therefore be a potential food or herb for preventing liver injuries.

引用

页数：9

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