T. rex attacks the lysosome

被引：0

作者：

Simon, Anna Katharina ^{[1
,2
]}

Ballabio, Andrea ^{[3
,4
,5
,6
]}

机构：

[1] John Radcliffe Hosp, MRC, Weatherall Inst Mol Med, Human Immunol Unit, Oxford OX3 9DU, England

[2] John Radcliffe Hosp, Biomed Res Ctr, Translat Immunol Lab, Nuffield Dept Med, Oxford OX3 9DU, England

[3] Telethon Inst Genet & Med, Naples, Italy

[4] Univ Naples Federico II, Dept Pediat Med Genet, Naples, Italy

[5] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[6] Texas Childrens Hosp, Jan & Dan Duncan Neurol Res Inst, Houston, TX 77030 USA

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

AUTOPHAGY; DNA; MECHANISM; CELLS;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mechanisms by which cells detect and fight foreign organisms is crucial for the host defense against infection. The sensing of cytosolic DNA is pivotal in this process, is kept in check by the exonuclease Trex1 and has been linked to lysosomal biogenesis via the transcription factor TFEB in an interferon-independent manner.

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页码：10 / 12

页数：3

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