High-throughput sequencing insights into T-cell receptor repertoire diversity in aging

被引：28

作者：

Goronzy, Joerg J. ^{[1
,2
]}

Qi, Qian ^{[1
,2
]}

Olshen, Richard A. ^{[3
]}

Weyand, Cornelia M. ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Dept Med, Div Rheumatol & Immunol, Stanford, CA 94305 USA

[2] VAPAHCS, Dept Med, Palo Alto, CA 94306 USA

[3] Stanford Univ, Sch Med, Dept Biomed Data Sci, Stanford, CA 94305 USA

来源：

GENOME MEDICINE | 2015年 / 7卷

关键词：

SELECTION; AGE;

D O I：

10.1186/s13073-015-0242-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity.

引用

页数：3

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