Current management of lupus nephritis

被引：44
|
作者：
Houssiau, Frederic A. [1 ]
Lauwerys, Bernard R. [1 ]
机构：
[1] Catholic Univ Louvain, Inst Rech Expt & Clin, Clin Univ St Luc, Pole & Serv Rhumatol, B-1200 Brussels, Belgium
来源：
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2013年 / 27卷 / 03期
关键词：
Lupus nephritis; Treatment; Immunosuppression; Optimal care; STAGE RENAL-DISEASE; TERM-FOLLOW-UP; MYCOPHENOLATE-MOFETIL; CONTROLLED-TRIAL; INTRAVENOUS CYCLOPHOSPHAMIDE; DOUBLE-BLIND; IMMUNOSUPPRESSIVE THERAPY; INDUCTION THERAPY; ORAL STEROIDS; ERYTHEMATOSUS;
D O I：
10.1016/j.berh.2013.07.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Despite decades of clinical research aimed at finding the most appropriate immunosuppressive regime, lupus nephritis (LN) remains one of the major disease manifestations of systemic lupus erythematosus (SLE) with a great impact on survival and quality of life. We start this review by defining the disease burden, the real-world challenges and the poor prognostic factors. We then discuss the current anti-inflammatory, cytotoxic and biologic therapies, with special emphasis on the need for optimal global care. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：319 / 328
页数：10
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