Metastasis suppressors in breast cancers: mechanistic insights and clinical potential

被引：41

作者：

Bohl, Christopher R. ^{[1
]}

Harihar, Sitaram ^{[1
]}

Denning, Warren L. ^{[1
]}

Sharma, Rahul ^{[1
]}

Welch, Danny R. ^{[1
,2
,3
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Canc Biol, Kansas City, KS 66160 USA

[2] Univ Kansas, Ctr Canc, Kansas City, KS 66160 USA

[3] Univ Kansas, Natl Fdn Canc Res, Ctr Metastasis Res, Kansas City, KS 66160 USA

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2014年 / 92卷 / 01期

关键词：

Metastasis suppressor; Nm23; BRMS1; KISS1; TIMP; E-cadherin; MKK4/6; KAI1; Adhesion; Invasion; MMP; Intravasation; Cohesion; Motility; Endothelium; Angiogenesis; Review; SQUAMOUS-CELL CARCINOMA; CHROMOSOME SEGMENT 11P15.5; KINASE INHIBITORY PROTEIN; FARNESOID X RECEPTOR; TUMOR-METASTASIS; PROSTATE-CANCER; POOR-PROGNOSIS; E-CADHERIN; REDUCED EXPRESSION; PANCREATIC-CANCER;

D O I：

10.1007/s00109-013-1109-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

For the most part, normal epithelial cells do not disseminate to other parts of the body and proliferate, as do metastatic cells. Presumably, a class of molecules-termed metastasis suppressors-are involved in this homeostatic control. Metastasis suppressors are, by definition, cellular factors that, when re-expressed in metastatic cells, functionally inhibit metastasis without significantly inhibiting tumor growth. In this brief review, we catalog known metastasis suppressors, what is known about their mechanism(s) of action, and experimental and clinical associations to date.

引用

页码：13 / 30

页数：18

共 122 条

[61] The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1 [J].

Lin, Yiwei ;

Wu, Yadi ;

Li, Junlin ;

Dong, Chenfang ;

Ye, Xiaofeng ;

Chi, Young-In ;

Evers, B. Mark ;

Zhou, Binhua P. .

EMBO JOURNAL, 2010, 29 (11) :1803-1816

[62] KAI1/CD82, a tumor metastasis suppressor [J].

Liu, Wei M. ;

Zhang, Xin A. .

CANCER LETTERS, 2006, 240 (02) :183-194

[63] N-myc downstream regulated gene 1 modulates Wnt-ß-catenin signalling and pleiotropically suppresses metastasis [J].

Liu, Wen ;

Xing, Fei ;

Iiizumi-Gairani, Megumi ;

Okuda, Hiroshi ;

Watabe, Misako ;

Pai, Sudha K. ;

Pandey, Puspa R. ;

Hirota, Shigeru ;

Kobayashi, Aya ;

Mo, Yin-Yuan ;

Fukuda, Koji ;

Li, Yi ;

Watabe, Kounosuke .

EMBO MOLECULAR MEDICINE, 2012, 4 (02) :93-108

[64] CD44 attenuates metastatic invasion during breast cancer progression [J].

Lopez, JI ;

Camenisch, TD ;

Stevens, MV ;

Sands, BJ ;

McDonald, J ;

Schroeder, JA .

CANCER RESEARCH, 2005, 65 (15) :6755-6763

[65] Understanding the Dual Nature of CD44 in Breast Cancer Progression [J].

Louderbough, Jeanne M. V. ;

Schroeder, Joyce A. .

MOLECULAR CANCER RESEARCH, 2011, 9 (12) :1573-1586

[66] miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis [J].

Ma, Li ;

Young, Jennifer ;

Prabhala, Harsha ;

Pan, Elizabeth ;

Mestdagh, Pieter ;

Muth, Daniel ;

Teruya-Feldstein, Julie ;

Reinhardt, Ferenc ;

Onder, Tamer T. ;

Valastyan, Scott ;

Westermann, Frank ;

Speleman, Frank ;

Vandesompele, Jo ;

Weinberg, Robert A. .

NATURE CELL BIOLOGY, 2010, 12 (03) :247-U52

[67]

Malik FA, 2009, HISTOL HISTOPATHOL, V24, P519, DOI 10.14670/HH-24.519

[68] The Metastasis Suppressor, N-myc Downregulated Gene 1 (NDRG1), Is a Prognostic Biomarker for Human Colorectal Cancer [J].

Mao, Zhihai ;

Sun, Jing ;

Feng, Bo ;

Ma, Junjun ;

Zang, Lu ;

Dong, Feng ;

Zhang, Daohai ;

Zheng, Minhua .

PLOS ONE, 2013, 8 (07)

[69] Protein-protein interactions: a mechanism regulating the anti-metastatic properties of Nm23-H1 [J].

Marino, Natascia ;

Marshall, Jean-Claude ;

Steeg, Patricia S. .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2011, 384 (4-5) :351-362

[70] Gas1 extends the range of Hedgehog action by facilitating its signaling [J].

Martinelli, David C. ;

Fan, Chen-Ming .

GENES & DEVELOPMENT, 2007, 21 (10) :1231-1243

← 2 3 4 5 6 7 8 9 10 11 →