Metastasis suppressors in breast cancers: mechanistic insights and clinical potential

被引：41

作者：

Bohl, Christopher R. ^{[1
]}

Harihar, Sitaram ^{[1
]}

Denning, Warren L. ^{[1
]}

Sharma, Rahul ^{[1
]}

Welch, Danny R. ^{[1
,2
,3
]}

机构：

[1] Univ Kansas, Med Ctr, Dept Canc Biol, Kansas City, KS 66160 USA

[2] Univ Kansas, Ctr Canc, Kansas City, KS 66160 USA

[3] Univ Kansas, Natl Fdn Canc Res, Ctr Metastasis Res, Kansas City, KS 66160 USA

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2014年 / 92卷 / 01期

关键词：

Metastasis suppressor; Nm23; BRMS1; KISS1; TIMP; E-cadherin; MKK4/6; KAI1; Adhesion; Invasion; MMP; Intravasation; Cohesion; Motility; Endothelium; Angiogenesis; Review; SQUAMOUS-CELL CARCINOMA; CHROMOSOME SEGMENT 11P15.5; KINASE INHIBITORY PROTEIN; FARNESOID X RECEPTOR; TUMOR-METASTASIS; PROSTATE-CANCER; POOR-PROGNOSIS; E-CADHERIN; REDUCED EXPRESSION; PANCREATIC-CANCER;

D O I：

10.1007/s00109-013-1109-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

For the most part, normal epithelial cells do not disseminate to other parts of the body and proliferate, as do metastatic cells. Presumably, a class of molecules-termed metastasis suppressors-are involved in this homeostatic control. Metastasis suppressors are, by definition, cellular factors that, when re-expressed in metastatic cells, functionally inhibit metastasis without significantly inhibiting tumor growth. In this brief review, we catalog known metastasis suppressors, what is known about their mechanism(s) of action, and experimental and clinical associations to date.

引用

页码：13 / 30

页数：18

共 122 条

[1] Low RKIP expression associates with poor prognosis in bladder cancer patients [J].

Afonso, Julieta ;

Longatto-Filho, Adhemar ;

Martinho, Olga ;

Lobo, Francisco ;

Amaro, Teresina ;

Reis, Rui M. ;

Santos, Lucio L. .

VIRCHOWS ARCHIV, 2013, 462 (04) :445-453

[2] MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4 [J].

Agarwal, N. ;

Adhikari, A. S. ;

Iyer, S. V. ;

Hekmatdoost, K. ;

Welch, D. R. ;

Iwakuma, T. .

ONCOGENE, 2013, 32 (04) :462-470

[3] MTBP plays a crucial role in mitotic progression and chromosome segregation [J].

Agarwal, N. ;

Tochigi, Y. ;

Adhikari, A. S. ;

Cui, S. ;

Cui, Y. ;

Iwakuma, T. .

CELL DEATH AND DIFFERENTIATION, 2011, 18 (07) :1208-1219

[4] The histone LSD1 demethylase in stemness and cancer transcription programs [J].

Amente, Stefano ;

Lania, Luigi ;

Majello, Barbara .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2013, 1829 (10) :981-986

[5] WNT signalling pathways as therapeutic targets in cancer [J].

Anastas, Jamie N. ;

Moon, Randall T. .

NATURE REVIEWS CANCER, 2013, 13 (01) :11-26

[6] Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma [J].

Ando, T. ;

Ishiguro, H. ;

Kimura, M. ;

Mitsui, A. ;

Kurehara, H. ;

Sugito, N. ;

Tomoda, K. ;

Mori, R. ;

Takashima, N. ;

Ogawa, R. ;

Fujii, Y. ;

Kuwabara, Y. .

DISEASES OF THE ESOPHAGUS, 2006, 19 (06) :454-458

[7]

Baig RM, 2013, DIS MARKERS, V34, P71, DOI [10.1155/2013/795410, 10.3233/DMA-120952]

[8] PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer [J].

Bandyopadhyay, S ;

Pai, SK ;

Hirota, S ;

Hosobe, S ;

Tsukada, T ;

Miura, K ;

Takano, Y ;

Saito, K ;

Commes, T ;

Piquemal, D ;

Watabe, M ;

Gross, S ;

Wang, Y ;

Huggenvik, J ;

Watabe, K .

CANCER RESEARCH, 2004, 64 (21) :7655-7660

[9] Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression [J].

Bandyopadhyay, S ;

Pai, SK ;

Hirota, S ;

Hosobe, S ;

Takano, Y ;

Saito, K ;

Piquemal, D ;

Commes, T ;

Watabe, M ;

Gross, SC ;

Wang, Y ;

Ran, S ;

Watabe, K .

ONCOGENE, 2004, 23 (33) :5675-5681

[10]

Bandyopadhyay S, 2003, CANCER RES, V63, P1731

← 1 2 3 4 5 6 7 8 9 10 →