The Role of MIF in Type 1 and Type 2 Diabetes Mellitus

被引：47
作者：
Sanchez-Zamora, Yuriko I. [1 ]
Rodriguez-Sosa, Miriam [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Tlalnepantla 54090, Mex, Mexico
来源：
JOURNAL OF DIABETES RESEARCH | 2014年 / 2014卷
关键词：
MIGRATION-INHIBITORY FACTOR; RHEUMATOID-ARTHRITIS; THERAPEUTIC TARGET; ADIPOSE-TISSUE; POLYMORPHISMS; ASSOCIATION; SERUM; DYSFUNCTION; EXPRESSION; RESISTANCE;
D O I：
10.1155/2014/804519
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Autoimmunity and chronic low-grade inflammation are hallmarks of diabetes mellitus type one (T1DM) and type two (T2DM), respectively. Both processes are orchestrated by inflammatory cytokines, including the macrophage migration inhibitory factor (MIF). To date, MIF has been implicated in both types of diabetes; therefore, understanding the role of MIF could affect our understanding of the autoimmune or inflammatory responses that influence diabetic pathology. This review highlights our current knowledge about the involvement of MIF in both types of diabetes in the clinical environment and in experimental disease models.
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页数：6
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