Phage-displayed peptides targeting specific tissues and organs

被引：31

作者：

Andrieu, Josu ^{[1
]}

Re, Francesca ^{[2
]}

Russo, Laura ^{[1
]}

Nicotra, Francesco ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, Milan, Italy

[2] Univ Milano Bicocca, Sch Med & Surg, Milan, Italy

来源：

JOURNAL OF DRUG TARGETING | 2019年 / 27卷 / 5-6期

基金：

欧盟地平线“2020”;

关键词：

Phage display; targeting peptides; drug delivery; VASCULAR ENDOTHELIAL-CELLS; HIGH-AFFINITY PEPTIDE; IN-VIVO; DRUG-DELIVERY; HOMING PEPTIDE; BINDING PEPTIDES; MOLECULAR HETEROGENEITY; CHITOSAN NANOPARTICLES; PANCREATIC-ISLETS; LIGANDS BINDING;

D O I：

10.1080/1061186X.2018.1531419

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Phage display is a powerful and widely used technique to find novel peptide ligands. A massive amount of peptide sequences have been identified for all kinds of materials, and peptides that may have targeting capabilities towards specific cells and tissues have received special attention in biomedical sciences. As a result, it is increasingly harder to follow all the work that has been done, which sometimes leads to many promising ligands receiving little attention, together with the publication of false positives that have already been found. The aim of this review is to provide an updated and comprehensive list of phage-displayed peptides targeting different tissues and organs. The limitations of the technique are carefully analysed and the future perspectives envisaged.

引用

页码：555 / 565

页数：11

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