HDAC1-mSin3a-NCOR1, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a regulate the NY-ESO1 gene expression

被引：40

作者：

Cartron, Pierre-Francois ^{[1
,2
]}

Blanquart, Christophe ^{[2
,3
]}

Hervouet, Eric ^{[1
,2
]}

Gregoire, Marc ^{[2
,3
]}

Vallette, Francois M. ^{[1
,2
,4
]}

机构：

[1] INSERM, Ctr Rech Cancerol Nantes Angers, Equipe Apoptose & Progress Tumorale, Equipe Labellisee Ligue Natl Canc,U892, F-44007 Nantes 1, France

[2] Univ Nantes, Fac Med, Dept Rech Cancerol, IFR26, F-4400 Nantes, France

[3] INSERM, Ctr Rech Cancerol Nantes Angers, Equipe Biol Cellules Dendrit Applicat Immunothera, U892, F-44007 Nantes 1, France

[4] Inst Cancerol Ouest, LaBCT, F-44805 Nantes, Saint Herblain, France

来源：

MOLECULAR ONCOLOGY | 2013年 / 7卷 / 03期

关键词：

Dnmt; Epigenetic; HDAC; NY-ESO1; Glioma; Mesothelioma; DNA METHYLATION; ANTIGEN-EXPRESSION; VALPROIC ACID; CELLS; MESOTHELIOMA; INHERITANCE; GLIOMA; TUMORS; DNMT1; HDAC1;

D O I：

10.1016/j.molonc.2012.11.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The NY-ESO1 gene is a cancer/testis antigen considered to be suitable target for the immunotherapy of human malignancies. Despite the identification of the epigenetical silencing of the NY-ESO1 gene in a large variety of tumors, the molecular mechanism involved in this phenomenon is not fully elucidated. In two non epithelial cancers (glioma and mesothelioma), we found that the epigenetic regulation of the NY-ESO1 gene requires the sequential recruitment of the HDAC1-mSin3a-NCOR, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a complexes. Thus, our data illustrate the orchestration of a sequential epigenetic mechanism including the histone deacetylation and methylation, and the DNA methylation processes. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：452 / 463

页数：12

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