Two New Diterpenoids from Cell Cultures of Salvia miltiorrhiza

被引：21

作者：

Zhang, De-Wu ^{[1
,2
]}

Liu, Xiao ^{[1
,2
]}

Xie, Dan ^{[1
,2
]}

Chen, Ridao ^{[1
,2
]}

Tao, Xiao-Yu ^{[1
,2
]}

Zou, Jian-Hua ^{[1
,2
]}

Dai, Jungui ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 05期

关键词：

diterpenoid; cell culture; Salvia miltiorrhiza; CONSTITUENTS; BUNGE; ROOTS;

D O I：

10.1248/cpb.c12-00987

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new spiroketallactone, epi-danshenspiroketallactone A (1) and a new C18-norditerpenoid, normiltioane (2) along with 21 known compounds, were isolated from cell cultures of Salvia miltiorrhiza. Their structures were elucidated on the basis of extensive spectroscopic analyses. In the in vitro assays, the compounds 9-11, 21-23 exhibited the significant antitumor activity with the IC50 ranges of 1.0-8.3 mu M.

引用

页码：576 / 580

页数：5

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