The cellular prion protein: a player in immunological quiescence

被引：37

作者：

Bakkebo, Maren K. ^{[1
]}

Mouillet-Richard, Sophie ^{[2
]}

Espenes, Arild ^{[1
]}

Goldmann, Wilfred ^{[3
]}

Tatzelt, Joerg ^{[4
]}

Tranulis, Michael A. ^{[1
]}

机构：

[1] Norwegian Univ Life Sci, Fac Vet Med & Biosci, Dept Basic Sci & Aquat Med, N-0033 Oslo, Norway

[2] Univ Paris 05, Sorbonne Paris Cite, INSERM, UMR S1124, Paris, France

[3] Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin Inst, Edinburgh EH9 1QH, Midlothian, Scotland

[4] Ruhr Univ Bochum, Inst Biochem & Pathobiochem, Biochem Neurodegenerat Dis, Bochum, Germany

来源：

FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

prion protein; immune privilege; immune modulation; cytoprotection; cell signaling; inflammation; neurodegeneration; Alzheimer; STRESS-INDUCIBLE PROTEIN-1; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; AMYLOID-BETA OLIGOMERS; N-TERMINAL FRAGMENT; IMMUNE PRIVILEGE; MOLECULAR-CLONING; MESSENGER-RNA; LYMPHOCYTE-ACTIVATION;

D O I：

10.3389/fimmu.2015.00450

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite intensive studies since the 1990s, the physiological role of the cellular prion protein (PrPc) remains elusive. Here, we present a novel concept suggesting that PrPL' contributes to immunological quiescence in addition to cell protection. PrPc is highly expressed in diverse organs that by multiple means are particularly protected from inflammation, such as the brain, eye, placenta, pregnant uterus, and testes, while at the same time it is expressed in most cells of the lymphoreticular system. In this paradigm, PrIp' serves two principal roles: to modulate the inflammatory potential of immune cells and to protect vulnerable parenchymal cells against noxious insults generated through inflammation. Here, we review studies of PrPL' physiology in view of this concept.

引用

页数：12

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